Assessments of sensory plasticity after spinal cord injury across species.
Assessments of sensory plasticity after spinal cord injury across species.
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DOI：
10.1016/j.neulet.2016.12.031
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发表时间：
2017-06-23
影响因子：
2.5
通讯作者：
Ferguson AR
中科院分区：
文献类型：
--
作者：
Haefeli J;Huie JR;Morioka K;Ferguson AR
脊髓损伤（SCI）是一种多方面的现象，与运动功能和感觉功能的改变有关。大多数SCI患者报告感觉障碍，不仅包括感觉丧失，而且在许多情况下还包括增强的异常感觉、感觉迟钝和疼痛。开发治疗这些异常感觉变化的疗法需要通用的测量工具，这些工具可以实现从动物模型到人类患者的跨物种翻译。我们回顾了目前的文献翻译伤害性感受/疼痛测量在SCI和讨论进一步发展的领域。虽然存在一些工具来测量节段性和情感性感觉变化，我们的结论是，迫切需要更好的，综合测量伤害性感受/疼痛的结果跨物种，以提高精确的治疗创新的感觉功能障碍在SCI。
Spinal cord injury (SCI) is a multifaceted phenomenon associated with alterations in both motor function and sensory function. A majority of patients with SCI report sensory disturbances, including not only loss of sensation, but in many cases enhanced abnormal sensation, dysesthesia and pain. Development of therapeutics to treat these abnormal sensory changes require common measurement tools that can enable cross-species translation from animal models to human patients. We review the current literature on translational nociception/pain measurement in SCI and discuss areas for further development. Although a number of tools exist for measuring both segmental and affective sensory changes, we conclude that there is a pressing need for better, integrative measurement of nociception/pain outcomes across species to enhance precise therapeutic innovation for sensory dysfunction in SCI.