Predictive factors of diabetic complications: a possible link between family history of diabetes and diabetic retinopathy.
Predictive factors of diabetic complications: a possible link between family history of diabetes and diabetic retinopathy.
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DOI：
10.1186/2251-6581-13-55
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发表时间：
2014
影响因子：
2.8
通讯作者：
Larijani B
中科院分区：
文献类型：
--
作者：
Maghbooli Z;Pasalar P;Keshtkar A;Farzadfar F;Larijani B
本研究的目的是评估糖尿病视网膜病变的预测因素。一项横断面研究的设计是在6个月的时间内（2012年7月至12月）从糖尿病转诊诊所招募1228名2型糖尿病患者。记录糖尿病危险因素、并发症、实验室检查结果。在1228例糖尿病患者中（54%为女性，平均年龄58.48 ± 9.94岁），糖尿病视网膜病变的患病率为26.6%。视网膜病变与糖尿病家族史（p = 0.04）、高血压（p = 0.0001）、糖尿病病程（p = 0.0001）、血糖控制不良（p = 0.0001）和糖尿病发病年龄（p = 0.0001）之间存在显著相关性。然而，没有发现视网膜病变与血脂异常和肥胖之间的显着关联。在logistic回归模型中，血糖控制不良（p = 0.014）、高血压（p = 0.0001）、糖尿病持续时间（p = 0.0001）和糖尿病家族史（p = 0.012）在调整年龄和性别后独立预测视网膜病变。糖尿病并发症是基因和环境因素相互作用的结果。糖尿病家族史提示糖尿病视网膜病变可能有遗传和表观遗传基础。我们的研究结果表明表观遗传修饰和代谢记忆在有糖尿病家族史的糖尿病视网膜病变中的作用。
The aim of this study was assessment of predictive factors of diabetic retinopathy. A cross-sectional study was designed by recruiting 1228 type 2 diabetic patients from a diabetes referral clinic over a six-month period (from July to December, 2012). Diabetes risk factors, complications, laboratory results have been recorded. Of the 1228 diabetic patients (54% women, mean age 58.48 ± 9.94 years), prevalence of diabetes retinopathy was 26.6%. There were significant associations between retinopathy and family history of diabetes (p = 0.04), hypertension (p = 0.0001), diabetic duration (p = 0.0001), poor glycemic control (p = 0.0001) and age of onset of diabetes (p = 0.0001). However, no significant associations were found between retinopathy with dyslipidemia and obesity. In logistic regression model, poor glycemic control (p = 0.014), hypertension (p = 0.0001), duration of diabetes (p = 0.0001) and family history of diabetes (p = 0.012) independently predicted retinopathy after adjustment for age and sex. Diabetic complications are resulting from an interaction from genes and environmental factors. A family history of diabetes is pointing toward a possible genetic and epigenetic basis for diabetic retinopathy. Our findings suggest the role of epigenetic modifications and metabolic memory in diabetic retinopathy in subjects with family history of diabetes.