Thinner prefrontal cortex in veterans with posttraumatic stress disorder
Thinner prefrontal cortex in veterans with posttraumatic stress disorder
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DOI：
10.1016/j.neuroimage.2008.03.007
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发表时间：
2008-07-01
期刊：
影响因子：
5.7
通讯作者：
Vermetten, Eric
中科院分区：
文献类型：
--
作者：
Geuze, Elbert;Westenberg, Herman G. M.;Vermetten, Eric
创伤后应激障碍（PTSD）的结构神经影像学研究主要集中在内侧颞叶的结构改变，只有少数研究了皮质中的灰质减少。计算分析的最新进展为使用半自动技术确定皮质厚度提供了新的机会，但这些技术尚未应用于PTSD。招募了25名患有PTSD的男性退伍军人和25名没有PTSD的男性退伍军人，年龄，年份和部署地区相匹配。所有受试者均进行MRI扫描。受试者的大脑使用基于感兴趣区域的方法中基于皮层的对齐进行对齐。根据MR图像计算个体皮质厚度图。检查的感兴趣区域包括双侧额上级回、双侧额中回、双侧额下回、双侧颞上级回和双侧颞中回。在大量的患者和对照组中，还获得了智商分数和记忆分数。根据MR图像计算个体皮质厚度图。患有创伤后应激障碍的退伍军人在双侧额中上级回、左侧额下回和左侧上级颞回的皮质厚度减少。与对照组相比，患有PTSD的退伍军人在记忆力方面表现得更差。在没有创伤后应激障碍的退伍军人中，皮质厚度与记忆测量相关，但在有创伤后应激障碍的退伍军人中则不相关。因此，这些区域的皮质变薄可能对应于在PTSD患者中观察到的功能异常。(C)2008年爱思唯尔公司All rights reserved.
Structural neuroimaging studies in posttraumatic stress disorder (PTSD) have focused primarily on structural alterations in the medial temporal lobe, and only a few have examined grey matter reductions in the cortex. Recent advances in computational analysis provide new opportunities to use semi-automatic techniques to determine cortical thickness, but these techniques have not yet been applied in PTSD. Twenty-five male veterans with PTSD and twenty-five male veterans without PTSD matched for age, year and region of deployment were recruited. All the subjects were scanned using MRI. Subjects' brains were aligned using cortex-based alignment in a region of interest based approach. Individual cortical thickness maps were calculated from the MR images. Regions of interest examined included the bilateral superior frontal gyri, bilateral middle frontal gyri, bilateral inferior frontal gyri, bilateral superior temporal gyri, and bilateral middle temporal gyri. In a large number of patients and controls, IQ scores and memory scores were also obtained. Individual cortical thickness maps were calculated from the MR images. Veterans with PTSD revealed reduced cortical thickness in the bilateral superior and middle frontal gyri, the left inferior frontal gyrus, and the left superior temporal gyrus. Veterans with PTSD performed significantly worse on memory measures compared to control veterans. Cortical thickness correlated with memory measures in the veterans without PTSD, but not in the veterans with PTSD. Cortical thinning in these regions may thus correspond to functional abnormalities observed in patients with PTSD. (C) 2008 Elsevier Inc. All rights reserved.