Vitamin D Receptor Polymorphisms and the Risk of Cutaneous Melanoma A Systematic Review and Meta-Analysis
Vitamin D Receptor Polymorphisms and the Risk of Cutaneous Melanoma A Systematic Review and Meta-Analysis
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DOI：
10.1002/cncr.23867
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发表时间：
2008-11-01
期刊：
影响因子：
6.2
通讯作者：
Nitti, Donato
中科院分区：
文献类型：
--
作者：
Mocellin, Simone;Nitti, Donato
人们假设维生素D受体(VDR)基因的多态会影响黑色素瘤的发病风险。然而，结果往往是相互矛盾的，而且到目前为止还没有对已发表的数据进行荟萃分析。检索和分析了6项研究(病例，2152例；对照，2410例)，调查了5个VDR基因(Taq1、Fok1、Bsm1、EcoRV和CDX2)与黑色素瘤风险的关系。无模型方法被用来对这些分子缔合研究进行荟萃分析。现有数据表明，BsmI VDR基因多态性与黑色素瘤风险显著相关(合并优势比[OR]，1.30；95%可信区间[CI]，1.11-1.53；P=.002；异质性Cochran Q检验，P>；.1)，人群归因风险为9.2%。相反，Fokl基因多态似乎与这种风险无关(OR，1.09；95%CI，0.99-1.21；P=0.07；异质性Cochran Q检验，P>；.1)。对于Taq1和EcoRV多态，显著的研究间异质性不支持基因型数据汇集。只有一项研究调查了CDX2变体，结果为阴性。目前的证据支持1 VDR基因Polvinogisin(Bsml)与发生黑色素瘤的风险之间的关联。目前的发现推动了对这一主题的进一步研究，并间接支持了阳光照射可能通过激活维生素D系统而产生全面抗黑色素瘤作用的假设。癌症2008年；第113期：2398407期。(C)2008年美国癌症协会。
It has been hypothesized that polymorphisms in the vitamin D receptor (VDR) gene affect the risk of developing melanoma. However, results often are conflicting, and no meta-analysis has been performed to date on published data. Six studies (cases, 2152; controls, 2410) that investigated the association between 5 VDR polymorphisms (Taql, Fokl, Bsml, EcoRV, and Cdx2) and the risk of melanoma were retrieved and analyzed. The model-free approach was applied to meta-analyze these molecular association studies. Available data Suggested a significant association between the BsmI VDR polymorphism and melanoma risk (pooled odds ratio [OR], 1.30; 95% confidence interval [CI], 1.11-1.53; P = .002; heterogeneity Cochran Q test, P > .1), and the population-attributable risk was 9.2%. In contrast, the Fokl polymorphism did not appear to be associated with such risk (OR, 1.09; 95% CI, 0.99-1.21; P = .07; heterogeneity Cochran Q test, P > .1). For the Taql and the EcoRV polymorphisms, significant between-study heterogencity did not support genotype data pooling. Only 1 study investigated the Cdx2 variant, and the findings were negative. Current evidence is in favor of an association between 1 VDR gene polvinorphisin (Bsml) and the risk of developing melanoma. The current findings prompt further investigation oil this subject and indirectly support the hypothesis that sun exposure may have ail antimelanoma effect through activation of the vitamin D system. Cancer 2008;113:2398407. (C) 2008 American Cancer Society.