Central autonomic modulation of cardiac baroreflex by corticotropin-releasing factor.
Central autonomic modulation of cardiac baroreflex by corticotropin-releasing factor.
复制标题
促肾上腺皮质激素释放因子对心脏压力反射的中枢自主调节。
DOI：
10.1152/ajpheart.1989.256.4.h949
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Fisher,LA
中科院分区：
文献类型：
--
作者：
Fisher,LA
本文研究了脑室注射促肾上腺皮质激素释放因子(CRF)对清醒自由大鼠压力感受性反射心率控制的影响。建立平均动脉压(MAP)与脉搏间期的刺激反应曲线，评价压力感受器反射功能。侧脑室注射CRF后，静息脉搏间期、反应幅度、反射增益、静息动脉压和MAP50(中等动脉压)的升高与剂量相关。用硝酸阿托品对心脏迷走神经的早期外周阻断可显著减弱CRF对静息脉搏间期、反应幅度和反射增益的影响。相反，静脉注射心得安早期阻断心脏交感神经的影响并没有改变CRF减少静息脉搏间期、反应范围和反射增益的能力。CRF对心脏压力感受器反射功能的中枢作用与硝酸阿托品的作用定性相似。结论：CRF改变了中枢神经系统通路的传递，介导了压力感受器对心脏迷走运动神经元的激活。
The effects of intracerebroventricular administration of corticotropin-releasing factor (CRF) on baroreflex control of heart rate were studied in conscious, unrestrained rats. Stimulus-response curves relating mean arterial pressure (MAP) to pulse interval were constructed for assessment of baroreflex function. CRF, intracerebroventricularly injected, elicited dose-related reductions of resting pulse interval, response range, and reflex gain and elevations of resting arterial pressure and MAP50 (arterial pressure at midrange). Earlier peripheral blockade of cardiac vagal influences with atropine methyl nitrate greatly attenuated the effects of CRF on resting pulse interval, response range, and reflex gain. In contrast, earlier blockade of cardiac sympathetic influences with intravenous propranolol treatment did not alter the ability of CRF to reduce resting pulse interval, response range, and reflex gain. The central nervous system effects of CRF on cardiac baroreflex function were qualitatively similar to the actions of atropine methyl nitrate. It is concluded that CRF alters transmission in central nervous system pathways mediating baroreceptor-induced activation of cardiac vagal motor neurons.