Stimulation of Prolactin and Growth Hormone Release by TRH Infused into a Hypophysial Portal Vessel 1
Stimulation of Prolactin and Growth Hormone Release by TRH Infused into a Hypophysial Portal Vessel 1
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TRH 注入垂体门静脉 1 刺激催乳素和生长激素释放
DOI：
10.3181/00379727-146-38200
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发表时间：
1974
影响因子：
--
通讯作者：
A. Schally
中科院分区：
文献类型：
--
作者：
J. Takahara;A. Arimura;A. Schally
研究了在乌拉坦麻醉下，将合成促甲状腺激素释放激素(TRH)注入正常雄性大鼠的垂体门静脉对催乳素和生长激素(GH)释放的影响。输注100 ng或更大剂量的人工合成TRH后，血清催乳素和生长激素水平持续升高，但较小剂量的TRH没有影响。50无花果雌二醇油预处理可提高基础催乳素和生长激素水平，但TRH后催乳素净增加不变，生长激素净增加略有减少。作者感谢J.Gauthier夫人和M.Esslinger夫人的出色技术援助，感谢Abba J.Kastin博士在准备手稿方面的帮助，感谢NIAMD大鼠垂体激素计划供应大鼠生长激素和催乳素RIA试剂盒。
Summary The effects of infusion of synthetic thytropin releasing hormone (TRH) into a hypophysial portal vessel on the release of prolactin and growth hormone (GH) were investigated in normal male rats under urethane anesthesia. Significant increases in serum prolactin and GH levels were consistently observed after the infusion of 100 ng or larger doses of synthetic TRH, but smaller doses had no effect. Pretreat-ment of rats with 50 fig estradiol in oil raised the basal levels of prolactin and GH, but the net increase after TRH remained the same for prolactin and was somewhat reduced for GH. The authors are indebted to Mrs. J. Gauthier and Mrs. M. Esslinger for their excellent technical assistance, Dr. Abba J. Kastin for his help in preparing the manuscript, and NIAMD Rat Pituitary Hormone Program for the supply of rat GH and Prolactin RIA Kits.