Current Capabilities of Gut Microbiome-Based Diagnostics and the Promise of Clinical Application
Current Capabilities of Gut Microbiome-Based Diagnostics and the Promise of Clinical Application
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DOI：
10.1093/infdis/jiaa689
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发表时间：
2021-06-15
影响因子：
6.4
通讯作者：
Kraft, Colleen S.
中科院分区：
文献类型：
--
作者：
Damhorst, Gregory L.;Adelman, Max W.;Kraft, Colleen S.
越来越多的证据表明肠道微生物组在人类健康和疾病中的重要性。传统和现代技术--从细胞培养到下一代测序--促进了这些知识的进步。用于测量微生物组的每种工具都具有独特的能力，可用于临床诊断。然而，仍然需要做很多工作来标准化微生物组的语言和指标。在这里，我们回顾了基于肠道微生物组的诊断能力，回顾了选定的例子，并讨论了临床应用的前景。
There is increasing evidence for the importance of the gut microbiome in human health and disease. Traditional and modern technologies - from cell culture to next generation sequencing - have facilitated these advances in knowledge. Each of the tools employed in measuring the microbiome exhibits unique capabilities that may be leveraged for clinical diagnostics. However, much still needs to be done to standardize the language and metrics by which a microbiome is characterized. Here we review the capabilities of gut microbiome-based diagnostics, review selected examples, and discuss the outlook towards clinical application.