Stem cells for the treatment of skeletal muscle injury.
Stem cells for the treatment of skeletal muscle injury.
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DOI：
10.1016/j.csm.2008.08.009
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发表时间：
2009-01
影响因子：
2
通讯作者：
Huard, Johnny
中科院分区：
文献类型：
--
作者：
Quintero, Andres J.;Wright, Vonda J.;Fu, Freddie H.;Huard, Johnny
Skeletal muscle injuries are extremely common, accounting for up to 35-55% of all sports injuries and quite possibly impacting all musculoskeletal traumas. These injuries result in the formation of fibrosis that may lead to development of painful contractures, increases their risk for repeat injuries, and limits their ability to return to a baseline or pre-injury level of function. The development of successful therapies for these injuries must consider the pathophysiology of these musculoskeletal conditions. We discuss the direct use of muscle-derived stem cells and some key cell population dynamics, as well as the use of clinically applicable modalities which may enhance the local supply of stem cells to the zone of injury by promoting angiogenesis.
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