Synthesis and Biological Evaluation of 4′-C-Methyl Nucleosides †
Synthesis and Biological Evaluation of 4′-C-Methyl Nucleosides †
复制标题
4′-C-甲基核苷的合成和生物学评价 †
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
H. Meguro
中科院分区：
文献类型：
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作者：
T. Waga;H. Ohrui;H. Meguro
摘要 合成了一系列 2'-脱氧、2',3'-不饱和和 2',3'-二脱氧核苷类似物，它们在 4'-位上有一个额外的甲基。当在 MT-4 细胞中评估其对 HIV 的抑制活性时，2'-脱氧-4'-C-甲基核苷表现出有效的活性。 †谨以此文纪念水野义久博士 75 岁生日。
Abstract A series of 2′-deoxy, 2′,3′-unsaturdted and 2′,3′-dideoxynucleoside analogues, which have an additional methyl group at the 4′-position, have been synthesized. When evaluated for their inhibitory activity against HIV in MT-4 cell, 2′-deoxy-4′-C-methyl nucleosides exhibited potent activity. †This paper is dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday.