Update on the types and usage of liquid biopsies in the clinical setting: a systematic review.
Update on the types and usage of liquid biopsies in the clinical setting: a systematic review.
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DOI：
10.1186/s12885-018-4433-3
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发表时间：
2018-05-04
期刊：
影响因子：
3.8
通讯作者：
Arneth B
中科院分区：
文献类型：
--
作者：
Arneth B
这项系统的综述旨在从医学实践中液体活组织检查的现状研究中收集证据，特别是关注突变检测和监测。通过Medline进行了系统的搜索。本研究的结果表明，液体活检在肿瘤的发现和处理中起着关键作用。这项技术使医疗保健提供者能够收集关键和可靠的信息，这些信息可能在不久的将来决定各种癌症的诊断、治疗和预后。这项研究进一步揭示了液体活组织检查有几个潜在的缺点，可能会限制其在医疗保健环境中的应用和使用。然而，液体活检仍然是一种有价值的工具，正逐渐成为世界各地肿瘤科和医院常规医疗实践的一部分。本文所描述的证据揭示了液体活检作为一种重要的预后、诊断和治疗工具的潜在相关性。这种非侵入性程序使医疗从业者能够检测和监测基因组变化，并可能取代肿瘤组织活组织检查，成为未来检测和监测突变的标准方法。这里获得的信息可以使医生对当前的治疗方案做出明智的决定；然而，液体活检尚未被纳入癌症患者的常规临床诊断。
This systematic review aimed to gather evidence from research on the current state of liquid biopsy in medical practice, specifically focusing on mutation detection and monitoring. A systematic search was performed via Medline. The results of this investigation indicate that liquid biopsy plays a critical role in the detection and management of tumors. This technique gives healthcare providers the ability to gather critical and reliable information that may potentially shape the diagnosis, treatment, and prognosis of a variety of cancers in the near future. This study further reveals that liquid biopsy has several potential shortcomings that may limit its application and use in the healthcare setting. Nevertheless, liquid biopsy remains a valuable tool that is gradually becoming a part of routine healthcare practice in oncology departments and hospitals worldwide. The evidence described herein reveals the potential relevance of liquid biopsy as an important prognostic, diagnostic, and theranostic tool. This non-invasive procedure enables healthcare practitioners to detect and monitor genomic alterations and will likely replace tumor tissue biopsy as the standard method for detecting and monitoring mutations in the future. The information obtained herein can enable physicians to make informed decisions regarding current treatment options; however, liquid biopsy has not yet been incorporated into routine clinical diagnostics for cancer patients.
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影响因子：
7.3
作者：
Carvalho J;Oliveira C
通讯作者：
Oliveira C
影响因子：
24.5
作者：
Church TR;Wandell M;Lofton-Day C;Mongin SJ;Burger M;Payne SR;Castaños-Vélez E;Blumenstein BA;Rösch T;Osborn N;Snover D;Day RW;Ransohoff DF;PRESEPT Clinical Study Steering Committee, Investigators and Study Team
通讯作者：
PRESEPT Clinical Study Steering Committee, Investigators and Study Team
DOI：
10.1126/science.1253462
发表时间：
2014-10-10
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
Swanton C
影响因子：
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作者：
Ansari J;Yun JW;Kompelli AR;Moufarrej YE;Alexander JS;Herrera GA;Shackelford RE
通讯作者：
Shackelford RE
DOI：
10.1016/j.gpb.2016.12.004
发表时间：
2017-04
期刊：
Genomics, proteomics & bioinformatics
影响因子：
--
作者：
Han X;Wang J;Sun Y
通讯作者：
Sun Y