Chemiosmotic mechanism of antimicrobial activity of Ag+ in Vibrio cholerae
Chemiosmotic mechanism of antimicrobial activity of Ag+ in Vibrio cholerae
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DOI：
10.1128/aac.46.8.2668-2670.2002
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发表时间：
2002-08-01
影响因子：
4.9
通讯作者：
Häse, CC
中科院分区：
文献类型：
--
作者：
Dibrov, P;Dzioba, J;Häse, CC
虽然银盐的抗菌作用很久以前就被注意到，但低浓度Ag+的杀菌作用的分子机制尚未阐明。在这里，我们表明，低浓度的Ag+诱导大量的质子泄漏通过霍乱弧菌膜，这将导致完全脱髓鞘，并具有很高的概率，细胞死亡。
Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag+ in low concentrations has not been elucidated. Here, we show that low concentrations of Ag+ induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.