Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery
Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery
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DOI：
10.1097/01.prs.0000234609.74811.2e
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发表时间：
2006-09-01
影响因子：
3.6
通讯作者：
Hedrick, Marc H.
中科院分区：
文献类型：
--
作者：
Moseley, Timothy A.;Zhu, Min;Hedrick, Marc H.
整形外科医生敏锐地意识到“以同类代替同类”的原则。尽管该手术存在缺点，但这一原则是临床使用自体脂肪移植背后的大部分原理的基础。自体脂肪移植经常用于各种美容和重建适应症，不仅限于面部和身体的创伤后缺陷、半面部萎缩等退化性疾病、放射治疗的后遗症，以及许多美容用途，例如唇部和面部增强和皱纹治疗。然而，脂肪移植的局限性是众所周知的，特别是体积维持的长期不可预测性。基于再生细胞的策略，例如那些包含使用干细胞的策略，对于扩大软组织空间具有巨大的希望。临床前研究和早期临床系列表明，脂肪干细胞有可能最终实现以同类替代美容填充剂的关键原则，并且没有现有技术的缺点。
Plastic surgeons are keenly aware of the principle "replace like with like." This principle underlies much of the rationale behind the clinical use of autologous fat transplantation, despite the procedure's drawbacks. Autologous fat transplantation is frequently used for a variety of cosmetic and reconstructive indications not limited to posttraumatic defects of the face and body, involutional disorders such as hemifacial atrophy, sequelae of radiation therapy, and many aesthetic uses such as lip and facial augmentation and wrinkle therapy. However, the limitations of fat transplantation are well known, particularly the long-term unpredictability of volume maintenance. Regenerative cell-based strategies such as those encompassing the use of stem cells hold tremendous promise for augmentation of the soft-tissue space. Preclinical studies and early clinical series show that adipose-derived stem cells offer the possibility of finally fulfilling the key principle of replacing like with like as an aesthetic filler, without the drawbacks of current technology.