Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer.
Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer.
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侵入性乳腺癌中预后微环境相关基因的全面分析。
DOI：
10.3389/fonc.2021.576911
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发表时间：
2021
影响因子：
4.7
通讯作者：
Yao F
中科院分区：
文献类型：
--
作者：
Shi Y;Chen S;Xing H;Jiang G;Wu N;Liu Q;Sakamoto N;Kuno T;Sugiura R;Xiao Q;Jin F;Fang Y;Yao F
最近的研究表明，肿瘤微环境有助于乳腺癌（BRCA）的发展，进展和治疗反应。然而，肿瘤微环境相关基因在BRCA的常规诊断检测或治疗决策中的作用仍然难以捉摸。通过ESTIMATE算法计算的免疫/基质/ESTIMATE评分量化了肿瘤中的免疫和基质成分，因此可以反映肿瘤微环境。为了研究肿瘤微环境相关基因与侵袭性BRCA预后的相关性，我们结合癌症基因组图谱（TCGA）数据库分析了侵袭性BRCA的免疫/基质/ESTIMATE评分。我们发现免疫/基质/ESTIMATE评分与浸润性BRCA临床病理因素显著相关。基于免疫/基质/ESTIMATE评分，我们提取了一系列与肿瘤微环境相关的差异表达基因（DEG）。进一步进行生存分析，以确定一系列高频DEG（HF-DEG），这些DEG在侵袭性BRCA中显示出预后价值。重要的是，与生物信息学分析结果一致，免疫组化结果显示SASH 3高表达与浸润性BRCA患者的良好预后相关。我们的研究结果表明，在这项研究中确定的肿瘤微环境相关的HF-DEG具有预后价值，并可能作为侵袭性BRCA的潜在生物标志物和治疗靶点。
Recent studies reveal that tumor microenvironment contributes to breast cancer (BRCA) development, progression, and therapeutic response. However, the contribution of the tumor microenvironment-related genes in routine diagnostic testing or therapeutic decision making for BRCA remains elusive. Immune/stromal/ESTIMATE scores calculated by the ESTIMATE algorithm quantify immune and stromal components in a tumor, and thus can reflect tumor microenvironment. To investigate the association of the tumor microenvironment-related genes with invasive BRCA prognosis, here we analyzed the immune/stromal/ESTIMATE scores in combination with The Cancer Genome Atlas (TCGA) database in invasive BRCA. We found that immune/stromal/ESTIMATE scores were significantly correlated with the invasive BRCA clinicopathological factors. Based on the immune/stromal/ESTIMATE scores, we extracted a series of differential expression genes (DEGs) related to the tumor microenvironment. Survival analysis was further performed to identify a list of high-frequency DEGs (HF-DEGs), which exhibited prognostic value in invasive BRCA. Importantly, consistent with the results of bioinformatics analysis, immunohistochemistry results showed that high SASH3 expression was associated with a good prognosis in invasive BRCA patients. Our findings suggest that the tumor microenvironment-related HF-DEGs identified in this study have prognostic values and may serve as potential biomarkers and therapeutic targets for invasive BRCA.
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影响因子：
--
作者：
Coyle KM;Murphy JP;Vidovic D;Vaghar-Kashani A;Dean CA;Sultan M;Clements D;Wallace M;Thomas ML;Hundert A;Giacomantonio CA;Helyer L;Gujar SA;Lee PW;Weaver IC;Marcato P
通讯作者：
Marcato P
影响因子：
4.7
作者：
Pelekanou V;Notas G;Athanasouli P;Alexakis K;Kiagiadaki F;Peroulis N;Kalyvianaki K;Kampouri E;Polioudaki H;Theodoropoulos P;Tsapis A;Castanas E;Kampa M
通讯作者：
Kampa M
DOI：
10.1016/j.biocel.2011.07.012
发表时间：
2011-11-01
影响因子：
4
作者：
Martini, Melanie;Gnann, Alexandra;Janssen, Klaus-Peter
通讯作者：
Janssen, Klaus-Peter
影响因子：
6
作者：
Hakulinen, J;Meri, S
通讯作者：
Meri, S
影响因子：
6.4
作者：
Miyamoto, K;Fukutomi, T;Ushijima, T
通讯作者：
Ushijima, T