Mortality risk and physical activity across the lifespan in endometrial cancer survivors.
Mortality risk and physical activity across the lifespan in endometrial cancer survivors.
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子宫内膜癌幸存者一生中的死亡风险和体力活动。
DOI：
10.1007/s10552-021-01540-z
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Cadmus-Bertram,LisaA
中科院分区：
文献类型：
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作者：
Gorzelitz,JessicaS;TrenthamDietz,Amy;Hampton,JohnM;Spencer,RyanJ;Costanzo,Erin;Koltyn,Kelli;Gangnon,RonaldE;Newcomb,PollyA;Cadmus-Bertram,LisaA
研究目的：在子宫内膜癌的预防和生存背景下，研究了身体活动（诊断前和诊断后）。然而，子宫内膜癌幸存者在整个生命周期中的身体活动（PA）对死亡风险的相关性研究不足。该研究的目的是确定终身PA对子宫内膜癌幸存者死亡风险的关联。（1991年至1994年诊断）报告频率在12岁、20岁和5年访视前（诊断后）进行中等强度和剧烈强度体力活动（MVPA）。使用考克斯比例风险估计2016年评估的PA、全因和心血管疾病死亡率之间相关性的风险比（HR）和95%置信区间。MVPA建模使用自然三次splines.ResultsDiagnosis年龄，体重指数，吸烟（包年）均呈正相关，增加全因死亡风险。与未进行MVPA的患者相比，在访视前5年进行一次MVPA的患者的死亡风险较低（HR 0.61; 95% CI 0.41-0.92）。那些报告一个会议MVPA在12岁（HR 0.95; 95%CI 0.86-1.06）和20岁（HR 0.87; 95%CI 0.65-1.16）时观察到类似的结果。虽然PA在12岁或20岁时不能独立保护死亡风险，但PA对子宫内膜癌幸存者的其他非死亡结局仍然很重要。
PurposePhysical activity (pre- and post-diagnosis) has been studied in prevention and survivorship contexts for endometrial cancer. However, the association of physical activity (PA) across the lifespan on mortality risk among endometrial cancer survivors is understudied. The study’s objective was to identify the association of lifetime PA on mortality risk in endometrial cancer survivors.MethodsSeven hundred forty-five endometrial cancer survivors drawn from a population-based cancer registry (diagnosed between 1991 and 1994) reported the frequency (sessions/week) of moderate- and vigorous intensity physical activity (MVPA) at age 12, age 20, and 5 years pre-interview (post-diagnosis). Cox proportional hazards were used to estimate hazard ratios (HR) and 95% confidence intervals for the association between PA, all-cause, and cardiovascular disease mortality as assessed in 2016. MVPA was modeled using natural cubic splines.ResultsDiagnosis age, body mass index, and smoking (pack-years) were each positively associated with increased all-cause mortality risk. Those who did one session of MVPA 5 years pre-interview had a lower mortality risk (HR 0.61; 95% CI 0.41–0.92) compared to those with no MVPA. Those reporting one session of MVPA was similarly observed at age 12 (HR 0.95; 95% CI 0.86–1.06) and at age 20 (HR 0.87; 95% CI 0.65–1.16).ConclusionThose who participated in PA, compared to those who did not, in the 5 years before diagnosis had a lower mortality risk. While PA was not independently protective against mortality risk at ages 12 or 20, PA is still important for endometrial cancer survivors for other non-mortality outcomes.