Mifepristone prevents the expression of long-term behavioural sensitization to amphetamine
Mifepristone prevents the expression of long-term behavioural sensitization to amphetamine
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DOI：
10.1016/0014-2999(96)00308-1
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发表时间：
1996-06-27
影响因子：
5
通讯作者：
Vanderschuren, LJMJ
中科院分区：
文献类型：
--
作者：
DeVries, J;Schoffelmeer, ANM;Vanderschuren, LJMJ
在间歇性苯丙胺暴露（2.5 mg/kg/天，持续5天）3周后，大鼠对苯丙胺激发表现出增强的运动反应。米非司酮（20毫克/公斤）给予45分钟前的挑战完全防止安非他明高反应性的表达。糖皮质激素拮抗剂并没有影响运动反应，以苯丙胺在药物幼稚大鼠。这些数据首次表明，糖皮质激素受体拮抗剂治疗可以预防有吸毒史的个体对滥用药物的长期高反应性。
Three weeks following intermittent amphetamine exposure (2.5 mg/kg/day for 5 days), rats showed an enhanced locomotor response to an amphetamine challenge. Mifepristone (20 mg/kg) given 45 min prior to the challenge completely prevented the expression of amphetamine hyperresponsiveness. The glucocorticoid antagonist did not affect the locomotor response to amphetamine in drug-naive rats. These data demonstrate for the first time that glucocorticoid receptor antagonist treatment may prevent long-term hyperreactivity to drugs of abuse in individuals with a drug history.