Calcium-channel subtypes in the somata and axon terminals of magnocellular neurosecretory cells
Calcium-channel subtypes in the somata and axon terminals of magnocellular neurosecretory cells
复制标题
DOI：
10.1016/0166-2236(96)10034-5
复制
发表时间：
1996-10
影响因子：
15.9
通讯作者：
T. Fisher;C. Bourque
中科院分区：
文献类型：
--
作者：
T. Fisher;C. Bourque
要了解钙通道类型的具体功能，有必要了解它们在神经元中的分布情况。大鼠视上核大细胞神经分泌细胞的独特结构使从成年大鼠分离的单个体细胞和轴突终末获得全细胞记录成为可能。对这些细胞中所诱发的钙电流的研究表明，某些类型的钙电流在胞体或轴突终末是分离的，而药理学定义的电流类型在这两个基因座上表现出不同的动力学特性。观察到的生物物理特性与两个隔室的功能需求相关，并对特定的钙通道亚型的作用有影响。趋势神经科学。(1996)19440-444
To understand the specific functions of Ca2+-channel types it is necessary to know how they are distributed within neurons. The unique structure of the magnocellular neurosecretory cells of the rat supraoptic nucleus has made it possible to obtain whole-cell recordings from individual somata and axon terminals acutely isolated from adult rats. Characterization of elicited Ca2+currents in these cells has demonstrated that certain types are segregated in somata or axon terminals, and that current types defined pharmacologically can display different kinetic properties in the two loci. Observed biophysical properties correlate with functional requirements in the two compartments and have implications for the roles of specific Ca2+-channel subtypes.Trends Neurosci. (1996) 19, 440–444