Indium-catalysed amide allylation of α-iminoamide: highly enantioselective synthesis of amide functionalised α-methylene-γ-butyrolactams
Indium-catalysed amide allylation of α-iminoamide: highly enantioselective synthesis of amide functionalised α-methylene-γ-butyrolactams
复制标题
α-亚氨基酰胺的铟催化酰胺烯丙基化：酰胺功能化 α-亚甲基-γ-丁内酰胺的高度对映选择性合成
DOI：
10.1039/c6ob02506d
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发表时间：
2017
影响因子：
3.2
通讯作者：
Hidemi Yoda
中科院分区：
文献类型：
--
作者：
Tetsuya Sengoku,Kana Kokubo;Masami Sakamoto;Masaki Takahashi; Hidemi Yoda
用催化量的InCl_3、ZnCl_2和BINOL衍生物实现了α-亚氨基酰胺的高对映选择性酰胺烯丙基化反应。该反应允许以优异的产率和高的对映选择性容易地获得各种酰胺官能化的α-亚甲基-γ-丁内酰胺。
A highly enantioselective amide allylation of α-iminoamides has been achieved using catalytic amounts of InCl3, ZnCl2 and a BINOL derivative. This reaction allowed facile access to a variety of amide functionalised α-methylene-γ-butyrolactams in excellent yields with high enantioselectivities.