Comparison of Gastroesophageal Reflux Disease Symptoms and Proton Pump Inhibitor Response Using Gastroesophageal Reflux Disease Impact Scale Questionnaire
Comparison of Gastroesophageal Reflux Disease Symptoms and Proton Pump Inhibitor Response Using Gastroesophageal Reflux Disease Impact Scale Questionnaire
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DOI：
10.5056/jnm.2013.19.1.61
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发表时间：
2013-01-01
影响因子：
3.4
通讯作者：
Jung, Hyun Chae
中科院分区：
文献类型：
--
作者：
Jo, So Young;Kim, Nayoung;Jung, Hyun Chae
目的采用胃食管反流病（GERD）影响量表（GIS）调查表比较糜烂性食管炎（EE）、非糜烂性反流病（NERD）和功能性烧心（FH）患者的GERD症状和质子泵抑制剂（PPI）的疗效。前瞻性进行24小时食管pH值检测和伯恩斯坦试验。结果EE组男性比例、经常饮酒、吸烟、食管裂孔疝、体重指数>= 25 kg/m2、甘油三酯水平>= 150 mg/dL均高于其他组（P均< 0.05）。FH患者的精神科治疗和精神药物治疗均高于EE和NERD患者（均P < 0.05）。胃食管反流症状中，FH组胸痛发生率高于EE组和NERD组（P < 0.05）。FH组和NERD组分别出现进食问题和生产性日常活动受限。PPI治疗8周后，EE组胃食管反流病症状明显改善（P均< 0.05），NERD组反酸、上腹痛、声音嘶哑明显改善（P均< 0.05）。在生活质量方面，PPI治疗改善了EE的睡眠障碍（P = 0.031）和NERD组（P = 0.001）的生产活动的限制。ConclusionsGIS问卷显示，不同的特点和症状改善后PPI治疗EE，NERD和FH患者，证明GIS问卷的有用性。
Background/AimsTo compare gastroesophageal reflux disease (GERD) symptoms and response to proton pump inhibitor (PPI) in patients with erosive esophagitis (EE), non-erosive reflux disease (NERD) or functional heartburn (FH) using GERD impact scale (GIS) questionnaire.MethodsTotal 126 patients with GERD symptoms were diagnosed as EE (n = 62), NERD (n = 34) and FH (n = 30) by endoscopy, 24-hour esophageal pH testing and Bernstein test, prospectively. Analysis of risk factors and GIS questionnaire for GERD symptoms and quality of life were performed before and 8 weeks after PPI treatment.ResultsEE group had a higher proportion of men, frequent alcohol consumption, smoking, hiatal hernia, body mass index >= 25 kg/m(2) and triglyceride levels (>= 150 mg/dL) than the other groups (all P < 0.05). On the other hand, both psychiatric treatment and psychopharmacotherapy were more frequent in patients with FH than in those with EE and NERD (both P < 0.05). Among GERD symptoms, chest pain was more frequent in FH group than in EE and NERD groups (P < 0.05). Eating problems and limitation of productive daily activities occurred frequently in FH group and NERD group, respectively. GIS after 8 week PPI treatment showed improvement in all of the GERD symptoms in EE (all P < 0.05) and in acid regurgitation, epigastric pain and hoarseness in NERD group (all P < 0.05). In terms of quality of life, PPI treatment improved sleep disturbance in EE (P = 0.031) and limitation of productive activity in the NERD group (P = 0.001).ConclusionsGIS questionnaire showed that different characteristics and symptoms improved after PPI therapy among patients with EE, NERD and FH, demonstrating the usefulness of the GIS questionnaire.