In Silico Insight into Potential Anti-Alzheimer's Disease Mechanisms of Icariin.
In Silico Insight into Potential Anti-Alzheimer's Disease Mechanisms of Icariin.
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DOI：
10.3390/ijms17010113
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发表时间：
2016-01-15
影响因子：
5.6
通讯作者：
Tang K
中科院分区：
文献类型：
--
作者：
Cui Z;Sheng Z;Yan X;Cao Z;Tang K
近年来，尽管临床晚期药物的研究进展缓慢，但人们还是发现了对阿尔茨海默病（AD）有显著疗效的中药复方。淫羊藿苷是从淫羊藿中分离得到的一种有效成分，在体内外研究中显示出显著的抗AD作用。然而，其分子机制至今仍不清楚。在这项工作中，淫羊藿苷的抗AD机制进行了研究，在目标网络水平的辅助下，在硅片目标识别程序（INVDOCK）。结果提示，淫羊藿苷的抗AD作用可能与抑制tau蛋白过度磷酸化、抗炎和调节Ca ~（2+）稳态有关。本研究结果为深入了解淫羊藿苷抗AD的分子机制和进一步开发淫羊藿苷抗AD药物提供了理论依据。
Herbal compounds that have notable therapeutic effect upon Alzheimer's disease (AD) have frequently been found, despite the recent failure of late-stage clinical drugs. Icariin, which is isolated from Epimedium brevicornum, is widely reported to exhibit significant anti-AD effects in in vitro and in vivo studies. However, the molecular mechanism remains thus far unclear. In this work, the anti-AD mechanisms of icariin were investigated at a target network level assisted by an in silico target identification program (INVDOCK). The results suggested that the anti-AD effects of icariin may be contributed by: attenuation of hyperphosphorylation of tau protein, anti-inflammation and regulation of Ca2+ homeostasis. Our results may provide assistance in understanding the molecular mechanism and further developing icariin into promising anti-AD agents.