A pilot naturalistic follow-up of extended sertraline treatment for severe premenstrual syndrome.
A pilot naturalistic follow-up of extended sertraline treatment for severe premenstrual syndrome.
复制标题
对严重经前综合症延长舍曲林治疗的试点自然随访。
DOI：
10.1097/01.jcp.0000126662.96529.6f
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发表时间：
2004
影响因子：
2.9
通讯作者：
Martin,PG
中科院分区：
文献类型：
--
作者：
Freeman,EllenW;Sondheimer,StevenJ;Rickels,Karl;Martin,PG
一名有双相情感障碍病史的 19 岁非裔美国男子在摄入 12,000 毫克喹硫平后 2.5 天就诊。据报道，他从床上摔下来，昏迷不醒，具体持续了多久。无癫痫病史，否认大小便失禁或咬舌头。入院时生命体征为血压129/80毫米汞柱，脉搏120，呼吸频率18，体温98.08华氏度。体检时，患者神志不清、烦躁不安，因疼痛而无法活动四肢。他的注意力下降，短期记忆受损。尿液药物筛查和血液酒精浓度均为阴性。没有证据表明患者摄入了其他物质，包括患者的其他两种药物：对乙酰氨基酚和丙戊酸。大脑计算机断层扫描显示没有异常发现。摄入后 2.5 天的入院实验室数据包括肌酸磷酸激酶 (CPK) 47,663、肌红蛋白 7267、血尿素氮 68、肌酐 4.5、天冬氨酸转氨酶 779、丙氨酸转氨酶 274 和磷 8.7。毒理学包括血清喹硫平 68 ng/mL、丙戊酸 57 Ag/mL 和对乙酰氨基酚 2 Ag/mL。 CPK 和肌红蛋白峰值分别为 96,073 和 5573（入院后 8 小时绘制）。
A 19-year-old African American man with a history of bipolar disorder presented 2.5 days after ingesting 12,000 mg quetiapine. He reported falling out of bed and lying unconscious for an unknown amount of time. He had no history of seizures and denied urinary or fecal incontinence or biting his tongue.Vital signs at the time of admission were blood pressure 129/80 mm Hg, pulse rate 120, respiratory rate 18, and temperature 98.08 F. On physical examination, the patient was confused, agitated, and unable to move his extremities due to pain. His concentration was decreased, and his short-term memory was impaired. Urine drug screen and blood alcohol level were negative. There was no evidence of ingestion of other substances, including the patient’s other 2 medications, acetaminophen and valproic acid. A computed tomography of the brain indicated no abnormal findings. Admission laboratory data 2.5 days after ingestion included creatine phosphokinase (CPK) 47,663, myoglobin 7267, blood urea nitrogen 68, creatinine 4.5, aspartate aminotransferase 779, alanine aminotransferase 274, and phosphorus 8.7. Toxicology included serum quetiapine 68 ng/mL, valproic acid 57 Ag/mL, and acetaminophen 2 Ag/mL. CPK and myoglobin peaked at 96,073 and 5573 (drawn 8 hours after admission).