HLA haplotypes are associated with differential susceptibility to Trypanosoma cruzi infection
HLA haplotypes are associated with differential susceptibility to Trypanosoma cruzi infection
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DOI：
10.1034/j.1399-0039.2000.550301.x
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发表时间：
2000-03-01
期刊：
影响因子：
--
通讯作者：
Martín, J
中科院分区：
文献类型：
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作者：
Nieto, A;Beraún, Y;Martín, J
我们探讨了HLA-II类基因在决定来自阿雷基帕的一个农村混血人群对克氏锥虫感染的易感性以及在发生查氏心脏病中的可能作用（南秘鲁），HLA-DRB 1和DQB 1多态性测定85血清阳性无症状组52例，心肌病组33例，血清学阴性组87例。克氏病高发区人群中克氏病感染的危险性（OR = 0.26（0.12-0.63）; P_c = 0.01）。这种保护性联合是一种显性性状。我们发现，在该人群中，无症状和心肌病患者之间的等位基因或单倍型分布没有差异。我们的数据提供了间接但令人信服的证据表明，HLA区域的多态性参与了对克氏锥虫慢性感染的不同易感性。
We explored a possible role of HLA class II genes in determining the susceptibility to Trypanosoma cruzi infection as well as in the development of chagasic heart disease in a rural mestizo population from Arequipa (Southern Peru), HLA-DRB1 and DQB1 polymorphisms were determined in 85 seropositive (asymptomatic, n=52; cardiomyopathic, n=33) and 87 seronegative individuals, We observed that the DRB1*14-DQB1*0301 haplotype correlates with not having T. cruzi infection in a highly endemic area (OR = 0.26 (0.12-0.63); P-c = 0.01). This protective association is a dominant trait. We found no differences in the allelic or haplotypic distributions we examined between asymptomatic and cardiomyopathic patients in this population. Our data offer indirect but compelling evidence that polymorphism in HLA region is involved in a differential susceptibility to T cruzi chronic infection.