B-cell activating factor as a serological biomarker for polymyositis and dermatomyositis
B-cell activating factor as a serological biomarker for polymyositis and dermatomyositis
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B 细胞激活因子作为多发性肌炎和皮肌炎的血清学生物标志物。
DOI：
10.2217/bmm.13.124
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发表时间：
2014-03-01
影响因子：
2.2
通讯作者：
Wang, Guo-Chun
中科院分区：
文献类型：
--
作者：
Peng, Qing-Lin;Shu, Xiao-Ming;Wang, Guo-Chun
目的：探讨多发性肌炎（PM）和皮肌炎（DM）患者血清B细胞活化因子（BAFF）水平及其与疾病活动性的关系。患者与方法：横断面分析包括92例PM/DM患者和25例健康对照者。一项纵向研究跟踪了24例患者。ELISA法检测血清BAFF浓度。结果：PM/DM患者血清BAFF水平显著高于健康对照组。横断面评估显示血清BAFF水平与总体疾病活动性之间存在中度相关性，血清BAFF水平与肌肉疾病活动性之间存在轻度相关性。纵向研究表明，血清BAFF水平与整体疾病活动和肌肉疾病活动适度相关。结论：结果数据显示PM/DM患者血清BAFF水平较高，并建议BAFF作为PM/DM疾病活动性的血清学生物标志物。
Aim: To investigate serum levels of B-cell activating factor (BAFF) in the patients with polymyositis (PM) and dermatomyositis (DM), and to systematically examine the association between serum BAFF levels and disease activity in PM/DM patients. Patients & methods: A cross-sectional analysis included 92 PM/DM patients and 25 healthy control subjects. A longitudinal study followed 24 patients. Serum BAFF concentrations were detected by the ELISA method. Results: Serum BAFF levels in PM/DM patients were significantly higher than those in healthy controls. A cross-sectional assessment revealed a modest correlation between serum BAFF levels and global disease activity and a mild correlation between serum BAFF levels and muscle disease activity. The longitudinal study showed that serum BAFF levels modestly correlated with global disease activity and muscle disease activity. Conclusion: Resulting data showed high serum BAFF levels in PM/DM patients and suggested BAFF as a serological biomarker for PM/DM disease activity.