Abdominal obesity and fatty liver
Abdominal obesity and fatty liver
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DOI：
10.1093/epirev/mxm002
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发表时间：
2007-01-01
影响因子：
5.5
通讯作者：
Overvad, K.
中科院分区：
文献类型：
--
作者：
Jakobsen, M. U.;Berentzen, T.;Overvad, K.
据推测，内脏脂肪释放游离脂肪酸和脂肪因子，从而使肝脏暴露于脂肪堆积。作者的目的是评估当前流行病学证据腹部脂肪和肝脏脂肪含量之间的关系。本文回顾了有关腹部脂肪和肝脏脂肪含量的临床和流行病学研究。用腰围来估计腹部脂肪量的研究表明，腹部脂肪和肝脏脂肪含量之间存在直接联系。影像学研究表明，腹内脂肪和肝脏脂肪含量之间存在直接关联，但腹部皮下脂肪和肝脏脂肪含量之间没有直接关联。总之，腹部脂肪和肝脏脂肪含量的临床和流行病学研究表明，腹部脂肪和肝脏脂肪含量之间存在直接关联，而肝脏脂肪含量可能是由内脏脂肪造成的。然而，纳入研究的结果并不能对事件的时间顺序作出强有力的结论。建议未来进行纵向研究，以获得有关关联和机制的更多信息。腹部脂肪库和其他感兴趣的身体隔室都应包括在内，以进一步研究特定脂肪库与肝脏脂肪含量之间的关系。生物标记物可能提供对潜在机制的洞察。
It has been hypothesized that visceral fat releases free fatty acids and adipokines and thereby exposes the liver to fat accumulation. The authors aimed to evaluate current epidemiologic evidence for an association between abdominal fat and liver fat content. Clinical and epidemiologic studies with data on abdominal fat and liver fat content were reviewed. Studies using waist circumference to estimate abdominal fat mass suggested a direct association between abdominal fat and liver fat content. Studies using imaging methods suggested a direct association between intraabdominal fat and liver fat content, but not between subcutaneous abdominal fat and liver fat content. In conclusion, clinical and epidemiologic studies of abdominal fat and liver fat content suggest a direct association between abdominal fat and liver fat content which is probably accounted for by visceral fat. However, results from the included studies do not allow strong conclusions regarding the temporal sequence of events. Future longitudinal studies are recommended to obtain additional information on associations and mechanisms. Both abdominal fat depots and other body compartments of interest should be included to further investigate the association between specific fat depots and liver fat content. Biomarkers may provide insight into underlying mechanisms.