Influence of Insulin Resistance on the Association Between Physical Activity and Heart Rate Variability: The Toon Health Study.
Influence of Insulin Resistance on the Association Between Physical Activity and Heart Rate Variability: The Toon Health Study.
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DOI：
10.1123/jpah.2020-0110
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发表时间：
2020-09
影响因子：
3.1
通讯作者：
I. Saito;K. Maruyama;Tadahiro Kato;Y. Takata;K. Tomooka;R. Kawamura;Yuichi Uesugi;Y. Naito;H. Osawa;T. Tanigawa
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文献类型：
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作者：
I. Saito;K. Maruyama;Tadahiro Kato;Y. Takata;K. Tomooka;R. Kawamura;Yuichi Uesugi;Y. Naito;H. Osawa;T. Tanigawa
自主神经活动可能受到身体活动（PA）的影响。然而，目前尚不清楚这种关联是否会被胰岛素抵抗所改变。方法：这项基于人群的研究于2009年至2012年进行，包括2016名年龄在30-79岁之间的男性和女性。使用基于睡眠、职业、交通、家庭特征和休闲时间PA的有效问卷来评估PA。坐姿时的心率（HR）和心率变异性（HRV）通过指尖传感器检测到的5分钟脉搏波记录来确定。HRV计算为频率（正态到正态[NN]区间的标准差[SDNN]）、连续差的均方根（RMSSD）、正常NN区间> - 50毫秒[pNN50]之间的百分比差和时域。采用稳态模型评估指数（HOMA-IR）评价胰岛素抵抗。结果在包含HOMA-IR的模型中，HR、RMSSD和pNN50与总PA和中/剧烈PA相关。每增加1-SD总PA的偏回归系数为。对数转换RMSSD为0.05 (P = .019)， pNN50为1.86 （P = .001）。PA与HOMA-IR之间无交互关联。结论：低总PA与HR升高、RMSSD和pNN50水平低相关，反映了副交感神经调节不受胰岛素抵抗的影响。
BACKGROUND Autonomic activity is possibly influenced by physical activity (PA). However, it remains unclear whether this association is modified by insulin resistance. METHODS This population-based study between 2009 and 2012 included 2016 men and women aged 30-79 years. The PA was assessed using a validated questionnaire based on sleep, occupation, transportation, household characteristics, and leisure-time PA. Heart rate (HR) and heart rate variability (HRV) in the sitting position were determined from 5-minute recordings of pulse waves detected by a fingertip sensor. The HRV was calculated as frequency (standard deviation of normal-to-normal [NN] intervals [SDNN]), root mean square of successive differences (RMSSD), and percentage differences between normal NN intervals >50 milliseconds [pNN50]) and time domains. Insulin resistance was evaluated using the homeostasis model assessment index (HOMA-IR). RESULTS HR, RMSSD, and pNN50 were related to the total and moderate/vigorous PA tertiles in models that included HOMA-IR. The partial regression coefficient of total PA per 1-SD increase was .05 (P = .019) for log-transformed RMSSD and 1.86 (P = .001) for pNN50. No interactive associations were observed between PA and HOMA-IR. CONCLUSIONS Low total PA was associated with increased HR and low levels of RMSSD and pNN50, reflecting parasympathetic modulation that was not modified by insulin resistance.