Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins.
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins.
复制标题
DOI：
10.1194/jlr.r000034
复制
发表时间：
2010-03
影响因子：
6.5
通讯作者：
Londos C
中科院分区：
文献类型：
--
作者：
Kimmel AR;Brasaemle DL;McAndrews-Hill M;Sztalryd C;Londos C
PAT蛋白家族在脊椎动物、昆虫和变形虫等多种真核生物中都有发现。这些蛋白质共享高度保守的序列组织和对细胞内中性脂质储存液滴表面的亲合力。目前对各成员的命名缺乏一致性和精确性，更多地来自历史背景，而不是对进化关系和共同功能的认识。在与小鼠基因组命名委员会、人类基因组组织基因组命名委员会以及2007年FASEB脂质滴会议：中性脂质储存的代谢后果的与会者协商后，我们为基因和蛋白质家族成员建立了统一的命名法。每个基因成员将并入词根术语PERILIPIN（PLIN），PAT家族的创始基因，不同的基因/蛋白质按顺序编号。
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.