Residential mobility during pregnancy and the potential for ambient air pollution exposure misclassification
Residential mobility during pregnancy and the potential for ambient air pollution exposure misclassification
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DOI：
10.1016/j.envres.2009.11.001
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发表时间：
2010-02-01
影响因子：
8.3
通讯作者：
Lin, Shao
中科院分区：
文献类型：
--
作者：
Chen, Lei;Bell, Erin M.;Lin, Shao
对环境暴露和不良出生结果的研究往往依赖于从出生证明中获得的母亲出生时的地址来对暴露进行分类。虽然感兴趣的胎龄通常是怀孕早期，但在使用从出生证明中提取的母亲地址时，无法获得怀孕期间搬家的妇女的母亲地址。本研究的目的是探讨环境空气污染物暴露分类错误的程度，由于产妇在怀孕期间的住宅流动性之间的一个纽约出生队列的亚组。作者从纽约出生证明中获得了母亲出生时的地址，并从1997-2002年研究期间的国家出生缺陷预防研究中获得了纽约参与者按胎龄列出的母亲地址。在1324名母亲中，172人（13.0%）在怀孕期间搬家一次，46人（3.5%）至少搬家两次。当考虑到一些人中的多个地址时，在218名搬家的母亲中，38名（2.9%）在怀孕后的第3至第8周（关键期，不包括妊娠前三个月）搬家，80名（6.0%）在妊娠前三个月搬家，112名（8.5%）在妊娠后三个月搬家，51名（3.9%）在妊娠后三个月搬家。空气监测数据从纽约环境保护部被用作替代计算环境臭氧和PM10暴露的母亲与完整的住宅数据。本研究使用出生证明中获得的出生时母亲地址估计暴露量，与使用母亲访谈中获得的孕龄母亲地址（金标准）估计暴露量相比。当使用基于访谈的地址和出生证明地址时，怀孕期间的平均暴露量相似（臭氧分别为0.035和0.035 ppm，PM10分别为20.11和20.09 μ g/m3）。计算Kappa统计量和一致性百分比，以测量二分暴露测量值（=中位数）的一致性程度，并按胎龄计算四分位暴露测量值的加权Kappa。所有的统计数据表明，两个测量之间的高度一致性。对于搬家的母亲来说，大多数人都保持着同一个暴露区域的地址。鉴于怀孕期间的低流动性和短距离移动，暴露分配没有实质性变化时，使用更准确的采访为基础的地址在这项研究中。然而，对于需要较小地理区域进行暴露分配或具有更多移动的研究人群的研究，观察到的一致性水平可能会降低。(C)2009 Elsevier Inc. All rights reserved.
Studies of environmental exposures and adverse birth outcomes often rely on maternal address at birth obtained from the birth certificate to classify exposure. Although the gestational age of interest is often early pregnancy, maternal addresses are not available for women who move during pregnancy when using maternal addresses abstracted from birth certificates. The aim of this study was to explore the extent of ambient air pollutant exposure misclassification due to maternal residential mobility during pregnancy among the subgroup of a New York birth cohort. The authors obtained the maternal addresses at birth from the New York Birth Certificate, and the maternal addresses by gestational age from the National Birth Defect Prevention Study for New York participants for the study period 1997-2002. Among the 1324 mothers, 172 (13.0%) moved once during pregnancy and 46 (3.5%) moved at least twice. When accounting for multiple addresses among some individuals, of the 218 mothers who moved, 38 (2.9%) moved in the 3rd to 8th weeks after conception (critical period, not exclusive from the 1st trimester), 80 (6.0%) moved in the 1st trimester, 112 (8.5%) in the 2nd trimester, and 51 (3.9%) in the 3rd trimester. Air monitoring data from the New York Department of Environmental Conservation were used as surrogates to compute the ambient ozone and PM10 exposures for mothers with complete residential data. This study estimates exposure using maternal address at birth obtained from birth certificates, compared to exposure estimates when using maternal addresses by gestational age obtained from maternal interview, the gold standard. Average exposures during pregnancy were similar when using interview based versus birth certificate addresses (0.035 vs. 0.035 ppm for ozone, and 20.11 vs. 20.09 mu g/m(3) for PM10, respectively). Kappa statistics and percent agreement were calculated to measure the degree of agreement for dichotomous exposure measurements ( = median) and weighted kappa for quartile exposure measurements by gestational age. All the statistics indicated a high agreement between the two measurements. For mothers who moved, the majority maintained their address in the same exposure region. Given the low mobility during pregnancy and the short distance moved, the exposure assignment did not change substantially when using the more accurate interview based addresses in this study. However, the level of observed agreement may decrease for studies that require smaller geographic zones for exposure assignments or with more mobile study populations. (C) 2009 Elsevier Inc. All rights reserved.