Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts.
Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts.
复制标题
DOI：
10.1016/j.jalz.2018.04.010
复制
发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Harvard Aging Brain Study
中科院分区：
文献类型：
--
作者：
Buckley RF;Mormino EC;Amariglio RE;Properzi MJ;Rabin JS;Lim YY;Papp KV;Jacobs HIL;Burnham S;Hanseeuw BJ;Doré V;Dobson A;Masters CL;Waller M;Rowe CC;Maruff P;Donohue MC;Rentz DM;Kirn D;Hedden T;Chhatwal J;Schultz AP;Johnson KA;Villemagne VL;Sperling RA;Alzheimer's Disease Neuroimaging Initiative;Australian Imaging, Biomarker and Lifestyle study of ageing;Harvard Aging Brain Study
我们的目的是研究在β-淀粉样蛋白（Aβ）负担和载脂蛋白（APOE）基因型的背景下，性别对认知能力下降的影响。我们分析了在ADNI、AIBL和HABS三个队列中，a - β- pet、APOE和临床前阿尔茨海默认知复合物-5 （PACC-5）的性别特异性影响(n=755，临床痴呆评分(CDR)=0；年龄(SD) = 73.6 (6.5);女= 55%)。对性别、a β- pet和APOEε4的认知变化混合效应模型进行二次时间效应检验，随访时间中位数为4年。APOEε4患病率和Aβ负担无性别差异。性并没有直接影响认知能力的下降。Aβ水平较高的女性比男性下降得更快。事后对比表明，Aβ和APOEε4阳性的女性比男性下降得更快。尽管Aβ没有性别差异，但Aβ较高的女性认知能力下降更大。我们的研究结果表明，性行为可能在ad相关认知能力下降的风险中起调节作用。
Our objective was to investigate the effect of sex on cognitive decline within the context of β-amyloid (Aβ) burden and apolipoprotein (APOE) genotype. We analyzed sex-specific effects on Aβ-PET, APOE and rates of change on the Preclinical Alzheimer Cognitive Composite-5 (PACC-5) across three cohorts, ADNI, AIBL and HABS (n=755; clinical dementia rating (CDR)=0; Age(SD)=73.6(6.5); Female=55%). Mixed-effects models of cognitive change by sex, Aβ-PET and APOEε4 were examined with quadratic time-effects over a median of 4 years of follow-up. APOEε4 prevalence and Aβ burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Aβ exhibited faster decline than males. Post-hoc contrasts suggested that females who were Aβ and APOEε4 positive declined faster than their male counterparts. Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest sex may play a modifying role on risk of AD-related cognitive decline.
登录
查看更多内容
影响因子：
5.7
作者：
Gross AL;Sherva R;Mukherjee S;Newhouse S;Kauwe JS;Munsie LM;Waterston LB;Bennett DA;Jones RN;Green RC;Crane PK;Alzheimer's Disease Neuroimaging Initiative;GENAROAD Consortium;AD Genetics Consortium
通讯作者：
AD Genetics Consortium
影响因子：
29
作者：
Donohue, Michael C.;Sperling, Reisa A.;Salmon, David P.;Rentz, Dorene M.;Raman, Rema;Thomas, Ronald G.;Weiner, Michael;Aisen, Paul S.
通讯作者：
Aisen, Paul S.
影响因子：
7.7
作者：
Domingue, Benjamin W.;Belsky, Daniel W.;Boardman, Jason D.
通讯作者：
Boardman, Jason D.
DOI：
10.1523/jneurosci.0305-12.2012
发表时间：
2012-06-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Damoiseaux JS;Seeley WW;Zhou J;Shirer WR;Coppola G;Karydas A;Rosen HJ;Miller BL;Kramer JH;Greicius MD;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
9.9
作者：
Barnes, LL;Wilson, RS;Bennett, DA
通讯作者：
Bennett, DA