HIGH-CONCENTRATIONS OF OXYTOCIN IN HYPOPHYSEAL PORTAL PLASMA
HIGH-CONCENTRATIONS OF OXYTOCIN IN HYPOPHYSEAL PORTAL PLASMA
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DOI：
10.1210/endo-114-4-1216
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发表时间：
1984-01-01
期刊：
影响因子：
4.8
通讯作者：
GIBBS, DM
中科院分区：
文献类型：
--
作者：
GIBBS, DM
取戊巴比妥钠麻醉的雄性大鼠垂体门静脉血，用放射免疫法测定催产素（OT）含量。门脉血浆中OT浓度为1.88 ± 0.001。0.48 ng/ml（平均值的标准误差），并且比来自相同大鼠的外周血浆样品中的OT浓度高至少15倍。门静脉血浆稀释液产生的位移曲线与合成OT和后叶提取物平行。数据支持OT作为下丘脑释放激素的可能作用。
Hypophyseal portal blood was collected from pentobarbital-anesthetized male rats, and the content of oxytocin (OT) was measured by radioimmunoassay. The concentration of OT in portal plasma was 1.88 .+-. 0.48 ng/ml (standard error of the mean) and was at least 15 times higher than the concentration of OT in peripheral plasma samples from the same rats. Dilutions of portal plasma produced a displacement curve parallel to those of synthetic OT and posterior lobe extract. The data support a possible role for OT as a hypothalamic-releasing hormone.