H5N1 pathogenesis studies in mammalian models
H5N1 pathogenesis studies in mammalian models
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DOI：
10.1016/j.virusres.2013.02.003
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发表时间：
2013-12-05
期刊：
影响因子：
5
通讯作者：
Tumpey, Terrence M.
中科院分区：
文献类型：
--
作者：
Belser, Jessica A.;Tumpey, Terrence M.
H5 N1流感病毒能够在人类中引起严重疾病和死亡，并且如果它们获得可传播的表型，则代表潜在的大流行亚型。由于这种病毒亚型的宿主和地理范围不断扩大，迫切需要更好地了解H5 N1病毒感染后病毒和宿主反应对预防和控制人类疾病的贡献。哺乳动物模型的使用，特别是小鼠和雪貂，使复杂的病毒-宿主相互作用以及影响毒力的单个病毒蛋白和点突变的贡献的详细研究成为可能。在这篇综述中，我们描述了H5 N1病毒在许多哺乳动物物种中表现出高毒力和低毒力的行为，并强调了接种途径对病毒致病性的贡献。参与宿主的反应，研究在近交和远交的哺乳动物模型进行了讨论。个别病毒的基因产物和分子决定因素，调节体内H5 N1疾病的严重程度的作用。这项研究不仅有助于我们了解流感病毒的发病机制，而且还确定了新的预防和治疗靶点，以减轻禽流感病毒造成的疾病负担。由爱思唯尔公司出版
H5N1 influenza viruses are capable of causing severe disease and death in humans, and represent a potential pandemic subtype should they acquire a transmissible phenotype. Due to the expanding host and geographic range of this virus subtype, there is an urgent need to better understand the contribution of both virus and host responses following H5N1 virus infection to prevent and control human disease. The use of mammalian models, notably the mouse and ferret, has enabled the detailed study of both complex virus-host interactions as well as the contribution of individual viral proteins and point mutations which influence virulence. In this review, we describe the behavior of H5N1 viruses which exhibit high and low virulence in numerous mammalian species, and highlight the contribution of inoculation route to virus pathogenicity. The involvement of host responses as studied in both inbred and outbred mammalian models is discussed. The roles of individual viral gene products and molecular determinants which modulate the severity of H5N1 disease in vivo are presented. This research contributes not only to our understanding of influenza virus pathogenesis, but also identifies novel preventative and therapeutic targets to mitigate the disease burden caused by avian influenza viruses. Published by Elsevier B.V.