Low vitamin D status is associated with more depressive symptoms in Dutch older adults.
Low vitamin D status is associated with more depressive symptoms in Dutch older adults.
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DOI：
10.1007/s00394-015-0970-6
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发表时间：
2016-06
影响因子：
5
通讯作者：
de Groot LC
中科院分区：
文献类型：
--
作者：
Brouwer-Brolsma EM;Dhonukshe-Rutten RA;van Wijngaarden JP;van der Zwaluw NL;Sohl E;In't Veld PH;van Dijk SC;Swart KM;Enneman AW;Ham AC;van Schoor NM;van der Velde N;Uitterlinden AG;Lips P;Feskens EJ;de Groot LC
大脑中维生素 D 受体的存在表明维生素 D 在大脑功能中可能发挥作用。我们研究了 2839 名 65 岁以上荷兰老年人的维生素 D 状态和维生素 D 相关基因构成与抑郁症状的关系。测量了 25-羟基维生素 D (25(OH)D)，并选择了 5 个“维生素 D 相关基因”。抑郁症状采用 15 点老年抑郁量表进行测量。结果以 25(OH)D 浓度四分位数或受影响等位基因数量表示为抑郁症状评分的相对风险，使用最低四分位数或次要等位基因组作为参考。观察到血清 25(OH)D 与抑郁症状评分之间存在清晰的横断面和前瞻性关联。完全调整的模型表明，第二、第三和第四组人群的抑郁症状评分分别降低了 22%（RR 0.78，95% CI 0.68–0.89）、21%（RR 0.79，95% CI 0.68–0.90）和 18%（RR 0.82，95% CI 0.71–0.95）。 25(OH)D 四分位数，与第一个四分位数的人相比 (P 对于趋势<0.0001）。每天补充 15 微克维生素 D 两年后，观察到了类似的关联。 25(OH)D 浓度与所选基因没有显着相互作用。低血清 25(OH)D 与较高的抑郁症状评分相关。未观察到 25(OH)D 浓度与维生素 D 基因组成之间存在相互作用。考虑到反向因果关系的可能性，我们建议应在前瞻性研究和随机对照试验中进一步检验这种关联。本文的在线版本 (doi:10.1007/s00394-015-0970-6) 包含补充材料，可供授权用户使用。
The existence of vitamin D receptors in the brain points to a possible role of vitamin D in brain function. We examined the association of vitamin D status and vitamin D-related genetic make-up with depressive symptoms amongst 2839 Dutch older adults aged ≥65 years. 25-Hydroxyvitamin D (25(OH)D) was measured, and five ‘vitamin D-related genes’ were selected. Depressive symptoms were measured with the 15-point Geriatric Depression Scale. Results were expressed as the relative risk of the score of depressive symptoms by quartiles of 25(OH)D concentration or number of affected alleles, using the lowest quartile or minor allele group as reference. A clear cross-sectional and prospective association between serum 25(OH)D and depressive symptom score was observed. Fully adjusted models indicated a 22 % (RR 0.78, 95 % CI 0.68–0.89), 21 % (RR 0.79, 95 % CI 0.68–0.90), and 18 % (RR 0.82, 95 % CI 0.71–0.95) lower score of depressive symptoms in people in the second, third, and fourth 25(OH)D quartiles, when compared to people in the first quartile (P for trend <0.0001). After 2 years of daily 15 µg vitamin D supplementation, similar associations were observed. 25(OH)D concentrations did not significantly interact with the selected genes. Low serum 25(OH)D was associated with higher depressive symptom scores. No interactions between 25(OH)D concentrations and vitamin D genetic make-up were observed. In view of the probability of reverse causation, we propose that the association should be further examined in prospective studies as well as in randomized controlled trials. The online version of this article (doi:10.1007/s00394-015-0970-6) contains supplementary material, which is available to authorized users.