Inflammatory and endothelial markers in women with polycystic ovary syndrome
Inflammatory and endothelial markers in women with polycystic ovary syndrome
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DOI：
10.1111/j.1365-2362.2006.01712.x
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发表时间：
2006-10-01
影响因子：
5.5
通讯作者：
Panidis, D.
中科院分区：
文献类型：
--
作者：
Diamanti-Kandarakis, E.;Alexandraki, K.;Panidis, D.
背景多囊卵巢综合征（PCOS）妇女携带心血管危险因素模式。内皮功能障碍和慢性炎症是动脉粥样硬化过程的早期发现。本研究的目的是探讨共存的活动性炎症标志物和内皮功能障碍的年轻女性PCOS，代谢和激素异常的syndrome.Materials and Methods 25个年轻女性PCOS和25个控制相似的年龄和体重指数（BMI）进行了研究。通过肱动脉血流介导的扩张（FMD）评估内皮功能，并通过硝酸盐诱导的扩张（NID）排除平滑肌细胞损伤。检测血浆内皮素-1（ET-1）、可溶性细胞间粘附分子-1（sICAM-1）、可溶性血管细胞粘附分子-1（sVCAM-1）和高敏C反应蛋白（hsCRP）水平。结果PCOS组血流介导的血管扩张（FMD）显著低于对照组（P < 0.001），而硝酸盐诱导的血管扩张（NID）两组无显著差异。多囊卵巢综合征（PCOS）组ET-1（P = 0.03）、sICAM-1（P = 0.01）、sVCAM-1（P = 0.02）和hsCRP（P = 0.01）水平明显高于对照组。hsCRP <1 mg L-1的PCOS患者FMD发生率高于hsCRP > 1 mg L-1的PCOS患者（P = 0.02）。血流介导的血管扩张（FMD）与hsCRP呈负相关ET-1与游离雄激素指数呈正相关（r =-0.512，P = 0.015）（r = 0.27，P = 0.05），与性激素结合球蛋白呈负相关sVCAM-1与总睾酮呈正相关（r =-0.465，P = 0.022）（r = 0.431，P = 0.036）; hsCRP与BMI呈正相关（r = 0.647，P = 0.001），与FMD呈负相关（r =-0.512，P = 0.015），定量胰岛素敏感性检查指数（QUICKI）（r =-0.499，P = 0.018），与松田指数（r =-0.445，P = 0.038），但不包括在内。结论内皮功能障碍与血清炎症水平的升高并存，并受血清炎症水平的影响。和内皮活化标志物的研究。这些参数似乎是相互关联的高雄激素血症在这个胰岛素抵抗的人口。
Background Women with polycystic ovary syndrome (PCOS) carry a pattern of cardiovascular risk factors. Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. The purpose of the study was to investigate the coexistence of active inflammation markers and endothelial dysfunction in young women with PCOS, and their relationship with metabolic and hormonal abnormalities of the syndrome.Materials and methods Twenty-five young women with PCOS and 25 controls of similar age and body mass index (BMI) were studied. Endothelial function was assessed by flow-mediated dilatation (FMD) on the brachial artery and smooth muscle cells injury was excluded by nitrate-induced dilatation (NID). Plasma levels of endothelin-1 (ET-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and high sensitivity C-reactive protein (hsCRP) were measured. Hormonal and metabolic profiles were determined in both groups.Results Flow-mediated dilatation (FMD) was statistically lower in PCOS (P < 0.001), whereas nitrate-induced dilatation (NID) was similar within the two groups. Polycystic ovary syndrome (PCOS) had statistically higher levels of ET-1 (P = 0.03), sICAM-1 (P = 0.01), sVCAM-1 (P = 0.02) and hsCRP (P = 0.01). Furthermore FMD was statistically higher in PCOS population with hsCRP 1 mg L-1 when compared with PCOS population with hsCRP > 1 mg L-1 (P = 0.02). Flow-mediated dilatation (FMD) was negatively related to hsCRP (r = -0.512, P = 0.015); ET-1 was positively related to free androgen index (r = 0.27, P = 0.05) and negatively to sex hormone-binding globulin (r = -0.465, P = 0.022); sVCAM-1 was positively related to total testosterone (r = 0.431, P = 0.036); hsCRP was positively related to BMI (r = 0.647, P = 0.001), and negatively related to FMD (r = -0.512, P = 0.015), quantitative insulin sensitivity check index (QUICKI) (r = -0.499, P = 0.018), and MATSUDA index (r = -0.445, P = 0.038).Conclusions The present study demonstrates that endothelial dysfunction coexists and is influenced by the presence of increased serum levels of inflammation and endothelial activation markers in young women with PCOS. These parameters appear to be interrelated with hyperandrogenaemia in this insulin-resistant population.