Spatial and non-spatial working memory at different stages of Parkinson's disease
Spatial and non-spatial working memory at different stages of Parkinson's disease
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DOI：
10.1016/s0028-3932(96)00101-7
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发表时间：
1997-04-01
期刊：
影响因子：
2.6
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Owen, AM;Iddon, JL;Robbins, TW
一组帕金森氏症患者，无论是服用药物还是未服用药物，在一系列旨在评估空间、语言和视觉工作记忆的计算机化测试中，与正常对照组进行了对比。在空间工作记忆任务中，受试者被要求系统地在多个方框中搜索以找到“标记”，同时避开那些先前发现标记的方框。在视觉和语言条件下，受试者被要求以完全相同的方式进行搜索，但分别通过一些抽象的设计或姓氏进行搜索，避免使用以前发现的标记的设计或名称。临床症状严重的内科帕金森病患者在所有三项工作记忆测试中都受到了损害。相比之下，临床症状轻微的服药患者在空间工作记忆测试上受到损害，但在言语或视觉工作记忆任务上没有受到影响。临床症状轻微的非药物治疗患者在所有三项任务中都没有受到损害。这些数据与之前一项研究的结果进行了比较，该研究比较了额叶、颞叶或杏仁海马区切除的神经外科患者组在相同的三项工作记忆测试中的结果。综上所述，这些发现表明，帕金森氏症患者的工作记忆缺陷会出现，随后会按照确定的顺序发展，其演变可能与纹状体内多巴胺耗尽的时空进程有关。与其皮质传入的终末分布有关。(C)1997年爱思唯尔科学有限公司。
Groups of patients with Parkinson's disease, either medicated or unmedicated, were compared with a matched group of normal control subjects on a computerized battery of tests designed to assess spatial, verbal and visual working memory. In the spatial working memory task, subjects were required to search systematically through a number of boxes to find 'tokens' whilst avoiding those boxes in which tokens had previously been found. In the visual and verbal conditions, the subjects were required to search in exactly the same manner, but through a number of abstract designs or surnames, respectively, avoiding designs or names in which a token had previously been found.Medicated Parkinson's disease patients with severe clinical symptoms were impaired on all three tests of working memory. In contrast, medicated patients with mild clinical symptoms were impaired on the test of spatial working memory, but not on the verbal or visual working memory tasks. Non-medicated patients with mild clinical symptoms were unimpaired on all three tasks.These data are compared with the results of a previous study comparing groups of neurosurgical patients with frontal, temporal or amygdalo-hippocampectomy excisions on the same three tests of working memory. Taken together, the findings suggest that working memory deficits in Parkinson's disease emerge, and subsequently progress, according to a defined sequence, the evolution of which may be linked to the likely spatiotemporal progression of dopamine depletion within the striatum. in relation to the terminal distribution of its cortical afferents. (C) 1997 Elsevier Science Ltd.