Mechanisms of allodynia: Interactions between sensitive mechanoreceptors and nociceptors
Mechanisms of allodynia: Interactions between sensitive mechanoreceptors and nociceptors
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DOI：
10.1097/00001756-199601310-00036
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发表时间：
1996-01-31
期刊：
影响因子：
1.7
通讯作者：
Laird, JMA
中科院分区：
文献类型：
--
作者：
Cervero, F;Laird, JMA
我们检查了来自异常性疼痛区域的敏感机械感受器的刺激是否会引起以轴突反射表达的伤害感受器活动。实验是在人类志愿者身上进行的。用激光多普勒流量计测量皮肤血流量。用芥子油（25-100%）或通过在前臂或手部皮肤皮内注射辣椒素（25-50μg）来诱发异常性疼痛。正常皮肤或异常性疼痛外部区域的触觉刺激不会引起轴突反射。对异常性疼痛区域的相同刺激会引起疼痛以及轴突反射。冷却原发性痛觉过敏区域或阻断支配异常性疼痛区域的神经中的 A 纤维可以消除异常性疼痛和轴突反射。这些结果证明了敏感机械感受器和伤害感受器之间伴随着异常性疼痛的发展的中心相互作用。
WE examined whether stimulation of sensitive mechanoreceptors from an area of allodynia evokes nociceptor activity expressed as axon reflexes. Experiments were conducted on human volunteers. Cutaneous blood flow was measured with a laser Doppler flowmeter. Allodynia was induced with mustard oil (25-100%) or by intradermal injections of capsaicin (25-50 mu g) in the skin of the forearm or the hand. Tactile stimulation of normal skin or outside zones of allodynia did not evoke axon reflexes. The same stimulation in areas of allodynia evoked pain as well as axon reflexes. Cooling the area of primary hyperalgesia or blocking the A fibres in the nerve that innervated the allodynia area abolished the allodynia and the axon reflex. These results demonstrate central interactions between sensitive mechanoreceptors and nociceptors concomitant with the development of allodynia.