Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects.
Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects.
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DOI：
10.4049/jimmunol.158.1.446
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发表时间：
1997-01
影响因子：
4.4
通讯作者：
W. Gilmore;Leslie P. Weiner;Jorge Correale
中科院分区：
文献类型：
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作者：
W. Gilmore;Leslie P. Weiner;Jorge Correale
从正常人和多发性硬化症患者分离的神经抗原特异性T细胞克隆，研究了雌二醇(E2)对CD4+T细胞分泌细胞因子的调节能力。在E2存在的情况下，大多数受试克隆对Ag刺激的IL-10的分泌有剂量依赖性的促进作用。干扰素-γ的分泌也被增强，尽管峰值增强发生在较低的E2浓度和比观察到的IL-10更低的幅度。相反，E_2对Ag刺激的肿瘤坏死因子-αβ分泌的影响是双相的，低剂量时有促进作用，高浓度时有抑制作用。E2对IL-4和TGF-β的分泌无影响。这些数据表明，E2能够调节CD4+T细胞的促炎和抗炎活性，因此有可能影响CD4+T细胞介导的免疫应答的结果。
The ability of estradiol (E2) to modulate the secretion of cytokines by CD4+ T cells was investigated using neuroantigen-specific T cell clones isolated from normal control subjects and patients with the demyelinating disease, multiple sclerosis. In the presence of E2, the majority of the tested clones showed a dose-dependent enhancement of Ag-stimulated IL-10 secretion. The secretion of IFN-gamma was also enhanced, although the peak enhancement occurred at lower E2 concentrations and at lower magnitude than observed for IL-10. By contrast, the effect of E2 on Ag-stimulated secretion of TNF-alphabeta was biphasic, with enhancement occurring at low doses, and inhibition present at high concentrations. E2 had no effect on the secretion of IL-4 or TGF-beta. These data indicate that E2 is capable of modulating both pro- and anti-inflammatory activities of CD4+ T cells and thus has the potential to influence the outcome of CD4+ T cell-mediated immune responsiveness.