Basilar artery blood flow velocity and the ventilatory response to acute hypoxia in mountaineers
Basilar artery blood flow velocity and the ventilatory response to acute hypoxia in mountaineers
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DOI：
10.1016/s1569-9048(02)00152-0
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发表时间：
2002-10-23
影响因子：
2.3
通讯作者：
Odoom, JA
中科院分区：
文献类型：
--
作者：
Jansen, GFA;Kagenaar, DA;Odoom, JA
成功的极限海拔登山者的缺氧通气反应高于对照组。我们假设这些登山者因缺氧而导致脑干血流量较低，这可能会导致髓质 CO(2) 滞留和更大的通气动力。使用经颅多普勒，在海平面测量了 7 名极端海拔登山者和 10 名对照者的基底动脉血流速度 (Vba)，连续暴露 10 分钟的吸入氧分数 (FI(O2)) 分别为 0.21（基线）、0.13、0.11、0.10、0.09、0.08 和 0.07。 FI(O2) 为 0.11（P < 0.05）、0.08 和 0.07（P < 0.0001）的登山者 Sa(O2) 较高。与对照组相比，登山者的呼气通气量 (V(E)) 增加更多（n.s.），而 PET(C02) 减少更多（n.s.）。 Fi(O2) 为 0.13-0.09 时，两组的 Vba 均无显着变化。当 FI(O2) 为 0.08 和 0.07 时，登山者中的 Vba 分别下降 21% (P < 0.03) 和 27% (P < 0.01)，而对照组分别增加 29% (P < 0.01) 和 27% (P < 0.01)。因此，缺氧和低碳酸血症对髓质血流和通气动力的相互矛盾的影响得以平衡，尽管PET（CO2）较低，脑干血流量较低，但登山者仍具有更大的动力和更高的Sa（O2）。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Hypoxic ventilatory response is higher in successful extreme-altitude climbers than in controls. We hypothesized that these climbers have lower brainstem blood flow secondary to hypoxia which may possibly cause retention of medullary CO(2) and greater ventilatory drive. Using transcranial Doppler, basilar artery blood flow velocity (Vba) was measured at sea level in 7 extreme-altitude climbers and 10 controls in response to 10 min sequential exposures to inspired oxygen fractions (FI(O2)) of 0.21 (baseline), 0.13, 0.11, 0.10, 0.09, 0.08 and 0.07. Sa(O2) was higher in climbers at FI(O2) of 0.11 (P < 0.05), 0.08 and 0.07 (both P < 0.0001). Expired ventilation (V(E)) increased more (n.s.), and PET(C02) decreased more (n.s.) in the climbers than in controls. Vba did not significantly change in both groups at Fi(O2) of 0.13-0.09. At FI(O2) of 0.08 and 0.07, Vba decreased 21% (P < 0.03) and 27% (P < 0.01), respectively, in climbers, and increased 29% (P < 0.01) and 27% (P < 0.01), respectively, in controls. The conflicting effects of hypoxia and hypocapnia on both medullary blood flow and ventilatory drive thus balance out, giving climbers a greater drive and higher Sa(O2), despite lower PET(CO2) and lower brain stem blood flow. (C) 2002 Elsevier Science B.V. All rights reserved.