Promotion of dendritic growth by CPG15, an activity-induced signaling molecule
Promotion of dendritic growth by CPG15, an activity-induced signaling molecule
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DOI：
10.1126/science.281.5384.1863
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发表时间：
1998-09-18
期刊：
影响因子：
56.9
通讯作者：
Cline, HT
中科院分区：
文献类型：
--
作者：
Nedivi, E;Wu, GY;Cline, HT
活动独立和活动依赖的机制协同工作来调节神经元的生长，确保形成准确的突触连接。Cpg15是一种受突触活性调节的蛋白质，在体内起着细胞表面促生长分子的作用。在非洲爪哇，cpg15促进投射神经元的树突状突起生长，而对中间神经元无影响。Cpg15通过一种细胞间信号机制控制邻近神经元的生长，这需要它的糖基磷脂酰肌醇连接。Cpg15可能代表了一类新的活性调节、膜结合、促进生长的蛋白质，允许对神经元结构进行精细的空间和时间控制。
Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. In Xenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neuron's through an intercellular signaling mechanism that requires, its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.