Admixture analysis of a rural population of the state of Guerrero, Mexico
Admixture analysis of a rural population of the state of Guerrero, Mexico
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DOI：
10.1002/ajpa.20227
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发表时间：
2005-12-01
影响因子：
2.8
通讯作者：
Shriver, MD
中科院分区：
文献类型：
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作者：
Bonilla, C;Gutiérrez, G;Shriver, MD
我们研究了来自墨西哥西部格雷罗州特拉帕市的156名美洲原住民后裔。大多数人的种族是Nahua，Mixtec或Tlapanec，但自我认同的Mestizos和混合种族的个人也包括在样本中。我们分型24个常染色体，Y染色体，和四个线粒体祖先信息标记（AIM），估计组和个人的混合比例，并确定是否混合过程中涉及父母组之间的定向基因流。当从分析中排除遗传定义（GD）的混血儿时，美洲原住民血统占人口基因库的98%，而欧洲和西非血统各占1%。母系遗传标记也显示出非常高的美洲原住民贡献（98.5%），父系遗传标记DYS 199（90.7%）也是如此。我们没有检测到遗传结构在这个群体中使用这些AIM，这似乎与混合比例方面的样品的同质性一致。添加GD Mestizos的样品没有产生相当大的变化，混合物的估计，但它对人口结构的重大影响。这些结果表明，在墨西哥的格雷罗的特拉巴种群与欧洲人和/或西非人的混合很少。他们还表明，少量的混合个体的影响，否则同质的人口可能有深远的影响，随后的祖先/表型分析和映射策略。我们认为，异质性是墨西哥人口的一个主要特点，因此，不应该被忽视时，设计墨西哥和墨西哥裔美国人的流行病学研究。
We studied 156 individuals of Native American descent from the city of Tlapa in the state of Guerrero in western Mexico. Most individuals' ethnicity was either Nahua, Mixtec, or Tlapanec, but self-identified Mestizos and individuals of mixed ethnicities were also included in the sample. We typed 24 autosomal, one Y-chromosome, and four mitochondrial ancestry-informative markers (AIMs) to estimate group and individual admixture proportions, and determine whether the admixture process involved directional gene flow between parental groups. When genetically defined (GD) Mestizos were excluded from the analysis, Native American ancestry represented similar to 98% of the population's gene pool, while European and West African ancestry represented similar to 1% each. Maternally inherited markers also showed an exceptionally high Native American contribution (98.5%), as did the paternally inherited marker, DYS199 (90.7%). We did not detect genetic structure in this population using these AIMs, which appears consistent with the homogeneity of the sample in terms of admixture proportions. The addition of GD Mestizos to the sample did not produce a considerable change in admixture estimates, but it had a major effect on population structure. These results show that the population of Tlapa in Guerrero, Mexico, has experienced little admixture with Europeans and/or West Africans. They also show that the impact of a small number of admixed individuals on an otherwise homogeneous population might have profound implications on subsequent ancestry/phenotype analysis and mapping strategies. We suggest that heterogeneity is a major characteristic of Mexican populations and, as a consequence, should not be disregarded when designing epidemiological studies of Mexican and Mexican American populations.