Serum Urate Levels and Consumption of Common Beverages and Alcohol Among Chinese in Singapore
Serum Urate Levels and Consumption of Common Beverages and Alcohol Among Chinese in Singapore
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DOI：
10.1002/acr.21999
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发表时间：
2013-08-01
影响因子：
4.7
通讯作者：
Koh, Woon-Puay
中科院分区：
文献类型：
--
作者：
Teng, Gim Gee;Tan, Chuen Seng;Koh, Woon-Puay
Objective.西方研究表明，饮料可能会影响血清尿酸盐（SU）水平，但亚洲人群的数据很少。我们评估了新加坡华人饮料和SU水平之间的关联。研究人群包括1993年至1998年期间从新加坡华人健康研究队列中招募的483名年龄在45-74岁之间的受试者。生活方式因素，病史和饮食通过面对面访谈收集。从1994年至1996年收集的血液中测量SU水平和其他生物标志物。平均年龄为57.6岁，44%为男性。几何平均SU水平为321摩尔/升（范围157-719）。平均SU水平随饮酒量增加而增加（趋势P = 0.024）。每日饮酒者的平均SU水平比不饮酒者高42.6摩尔/升。同样，绿色茶摄入频率的增加与SU水平的升高有关。每日饮用绿色茶者（差异为25.0摩尔/升）与不饮用者相比，平均SU水平最高（趋势P = 0.009）。与不饮酒者相比，每日饮酒者与高尿酸血症的相关性增加了近5倍（比值比[OR] 4.83，95%置信区间[95% CI] 1.10-21.23），而每日饮用绿色茶者与高尿酸血症的相关性增加了2倍（OR 2.12，95% CI 1.03-4.36）。本研究并未显示饮用红茶、咖啡、果汁或苏打水的个体SU水平升高。饮酒会增加SU水平。每天饮用绿色茶与高尿酸血症相关的发现需要在未来的研究中验证。
Objective. Western studies suggest that beverages may affect serum urate (SU) levels, but data from Asian populations are scarce. We evaluated the associations between beverages and SU levels in Singaporean Chinese.Methods. The study population consisted of 483 subjects ages 45-74 years from the Singapore Chinese Health Study cohort, recruited between 1993 and 1998. Lifestyle factors, medical histories, and diet were collected through in-person interviews. SU levels and other biomarkers were measured from blood collected between 1994 and 1996.Results. The mean age was 57.6 years and 44% were men. The geometric mean SU level was 321 moles/liter (range 157-719). Mean SU levels increased with alcohol consumption (P = 0.024 for trend). The mean SU level of daily alcohol drinkers was 42.6 moles/liter higher than that of nondrinkers. Similarly, increasing frequency of green tea intake was associated with rising SU levels. The highest mean SU level was observed in daily green tea drinkers (difference of 25.0 moles/liter) relative to nondrinkers (P = 0.009 for trend). Compared to nondrinkers, daily alcohol drinkers had an almost 5-fold increase in association with hyperuricemia (odds ratio [OR] 4.83, 95% confidence interval [95% CI] 1.10-21.23), whereas daily green tea drinkers had a 2-fold increase in association with hyperuricemia (OR 2.12, 95% CI 1.03-4.36). The present study did not show elevated levels of SU in individuals who consumed black tea, coffee, fruit juice, or soda.Conclusion. Alcohol consumption increases SU levels. The finding that daily drinking of green tea is associated with hyperuricemia needs validation in future studies.