THE INFLUENCE OF SYMPTOMS OF DISEASE AND SIDE-EFFECTS OF TREATMENT ON COMPLIANCE WITH CANCER-THERAPY
THE INFLUENCE OF SYMPTOMS OF DISEASE AND SIDE-EFFECTS OF TREATMENT ON COMPLIANCE WITH CANCER-THERAPY
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DOI：
10.1200/jco.1988.6.11.1746
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发表时间：
1988-11-01
影响因子：
45.3
通讯作者：
LEVINE, A
中科院分区：
文献类型：
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作者：
RICHARDSON, JL;MARKS, G;LEVINE, A
为了系统分析癌症治疗的不良症状和副作用与患者治疗不依从性的关系，我们在治疗开始时和6个月后采访了107例血液恶性肿瘤患者，以收集有关所经历的不愉快身体效应的类型，频率和难度的信息。每月监测（生化和自我报告）口服别嘌呤醇和泼尼松的依从性水平。还监测了保持接受输注化疗的意愿。恶心是最常见的副作用。恶心、发烧和疼痛是发生时最难忍受的身体反应。复杂的治疗方案和严重疾病相关的报告或更多的身体影响。年轻患者比老年患者更难处理这些影响。与两种自我给药药物中任何一种的不依从性相关的任何影响的发生率、频率或处理困难均不存在。特殊效果的困难确实与不遵守诊所预约接受灌注化疗有关。
To provide a systematic analysis of how adverse symptoms of disease and side effects of cancer therapy relate to patient noncompliance with treatment, we interviewed 107 patients with hematologic malignancies at the initiation of therapy and 6 months later to collect information on the type, frequency, and difficulty of unpleasant physical effects experienced. Level of compliance was monitored (biochemically and with self-report) on a monthly basis for oral self administration of allopurinol and prednisone. Appointment-keeping to receive infused chemotherapy was also monitored. Nausea was the most frequent side effect experienced. Nausea, fever, and pain were the most difficult physical effects to tolerate when they occurred. Complex treatment regimens and severe diseases related to reports or more physical effects. Younger patients had a more difficult time dealing with these effects than did older patients. Neither the occurrence, frequency, or difficulty dealing with any of the effects related to noncompliance with either of the two self-administered medications. Difficulty with particular effects did relate to noncompliance with clinic appointments to receive infused chemotherapy.