Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan
Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan
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DOI：
10.3748/wjg.v16.i4.474
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发表时间：
2010-01-28
影响因子：
4.3
通讯作者：
Con-Wong, Reinaldo
中科院分区：
文献类型：
--
作者：
Con, Sergio A.;Takeuchi, Hiroaki;Con-Wong, Reinaldo
目的：探讨在哥斯达黎加和日本临床分离株中幽门螺杆菌(Hp)BabA2、BabB和BabA2和BabB之间的重组基因(BabA2/8)的感染率及其在萎缩性胃炎发生中的作用。方法：2005年10月至2006年7月，95例连续Hp阳性的哥斯达黎加患者(男性41例，女性54例；平均年龄50.65岁；SD，+/-13.04岁)和Hp持续阳性的日本患者95例(男性50例，女性45例；平均年龄63.43岁；SD，+/-13.21岁)。他们参加了基于聚合酶链式反应的幽门螺杆菌BabA2、BabB和BabA2/B基因的基因分型。统计分析采用卡方检验和Fisher精确概率检验，多因素分析采用Logistic回归校正性别和年龄因素。P
AIM: To evaluate the prevalence of Helicobacter pylori (H. pylori) babA2, babB and a recombinant gene between babA2 and babB (babA2/8), and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS: A total of 95 continuous H. pylori-positive Costa Rican (41 males and 54 females; mean age, 50.65 years; SD, +/- 13.04 years) and 95 continuous H. pylori-positive Japanese (50 males and 45 females; mean age, 63.43; SD, +/- 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006. They were enrolled for the polymerase chain reaction (PCR)-based genotyping of the H. pylori babA2, babB and babA2/B genes. Statistical analysis was performed using the chi(2) test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age. P