Comparison of the early effects of vonoprazan, lansoprazole and famotidine on intragastric pH: a three-way crossover study.
Comparison of the early effects of vonoprazan, lansoprazole and famotidine on intragastric pH: a three-way crossover study.
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DOI：
10.3164/jcbn.17-128
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发表时间：
2018-07
影响因子：
2.4
通讯作者：
Nakajima A
中科院分区：
文献类型：
--
作者：
Ohkuma K;Iida H;Inoh Y;Kanoshima K;Ohkubo H;Nonaka T;Fujita K;Kusakabe A;Inamori M;Nakajima A
为了促进酸相关疾病的症状缓解，一种具有快速起效的药物是理想的。本研究的目的是研究单次口服新型质子泵抑制剂vonoprazan对胃酸分泌的早期抑制作用，并与兰索拉唑和法莫替丁进行比较。10名幽门螺杆菌（HP）阴性的男性受试者参加了这项随机、三向交叉研究。单次口服伏诺哌赞（20mg）、兰索拉唑（30mg）或法莫替丁（20mg），连续监测胃内pH值6小时。每药间隔至少7天。法莫替丁给药后6 h平均胃内pH高于兰索拉唑给药后6 h平均胃内pH（中位数：4.45 vs 2.65; p = 0.0284）。沃诺哌赞和兰索拉唑的结果相似（中位数：4.30 vs 2.65; p = 0.0322）。综上所述，在hp阴性的健康男性受试者中口服伏诺哌赞和法莫替丁可使胃内pH值比兰索拉唑升高得更快。（试验注册号：UMIN000020989）
To promote symptom relief from acid-related diseases, a medicine with a rapid-onset effect is ideal. The aim of this study was to investigate the early inhibitory effect on gastric acid secretion after a single oral administration of vonoprazan, which represents a new class of proton pump inhibitors, and to compare this effect with those of lansoprazole and famotidine. Ten Helicobacter pylori (HP)-negative male subjects participated in this randomized, three-way crossover study. A single oral administration of vonoprazan (20 mg), lansoprazole (30 mg) or famotidine (20 mg) was performed, and the intragastric pH was continuously monitored for 6 h. Each drug was administered at least seven days apart. The average intragastric pH during the 6-h period after the administration of famotidine was higher than that after the administration of lansoprazole (median: 4.45 vs 2.65; p = 0.0284). A similar result was observed for vonoprazan and lansoprazole (median: 4.30 vs 2.65; p = 0.0322). In conclusions, oral administration of vonoprazan and famotidine in HP-negative healthy male subjects caused the intragastric pH to rise more quickly than did lansoprazole. (Trial Registration: UMIN000020989)