Immunochemical staining of MT2-MMP correlates positively to angiogenesis of human esophageal cancer.
Immunochemical staining of MT2-MMP correlates positively to angiogenesis of human esophageal cancer.
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发表时间：
2010-10
影响因子：
2
通讯作者：
Lujun Chen;Dongmei Di;G. Luo;Lu Zheng;Yan Tan;Xiaoying Zhang;N. Xu
中科院分区：
文献类型：
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作者：
Lujun Chen;Dongmei Di;G. Luo;Lu Zheng;Yan Tan;Xiaoying Zhang;N. Xu
基质金属蛋白酶（Matrix metalloproteinases，MMPs）在细胞外基质降解、基底膜破坏等病理过程中发挥重要作用，导致肿瘤的侵袭和转移。本研究检测了103例食管癌组织中膜型2型基质金属蛋白酶（MT 2-MMP）的表达，并探讨了MT 2-MMP表达与患者临床病理特征、肿瘤内血管生成及术后复发的关系。MT 2-MMP免疫组化染色强度与食管癌组织中血管生成呈显著正相关。MT 2-MMP免疫反应阳性率为85.4%，而在正常食管组织中无或非常弱。MT 2-MMP免疫组化强度与肿瘤大小显著相关，而与患者性别、年龄、浸润深度、淋巴结转移和远处转移无关。MT 2-MMP水平不能预测患者的生存率，尽管H评分截断值显示MT 2-MMP蛋白低水平患者的总生存率优于MT 2-MMP蛋白高水平患者。
Matrix metalloproteinases (MMPs) play an important role in the pathological processes of degradation of extracellular matrix and destruction of basement membrane, which leads to tumor invasion and metastasis. In the present study, we investigated membrane-type 2 MMP (MT2-MMP) expression pattern in esophageal cancer tissues collected from 103 patients, and explored MT2-MMP expression pattern in correlation to patients' clinicopathological features, intratumoral angiogenesis and postoperative prognoses. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. Positive MT2-MMP immunoreactions were found in 85.4% of total tumor sections, whereas none or very weak MT2-MMP staining occurred in normal esophageal tissues. In addition, MT2-MMP immunochemical intensities were significantly correlated to tumor size, but not to patient's gender, age, invasion depth, lymph node metastasis and distant metastasis. Moreover, MT2-MMP levels could not be applied for predicting patients' survival rate although the H-score cut-off value showed the overall survival rate of patients with low MT2-MMP protein level to be better than those with high MT2-MMP protein level.