CXCR4/SDF-1 pathway is crucial for TLR9 agonist enhanced metastasis of human lung cancer cell
CXCR4/SDF-1 pathway is crucial for TLR9 agonist enhanced metastasis of human lung cancer cell
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DOI：
10.1016/j.bbrc.2009.03.072
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发表时间：
2009-05-08
影响因子：
3.1
通讯作者：
Wen, Zhen-Ke
中科院分区：
文献类型：
--
作者：
Xu, Lin;Zhou, Ya;Wen, Zhen-Ke
越来越多的研究表明CXCR 4/SDF-1通路可能在肿瘤的转移过程中发挥重要作用。我们以前证明CpG ODN可以通过TLR 9增强人肺癌细胞的转移。本研究进一步探讨CXCR 4/SDF-1通路在CpG ODN诱导人肺癌95 D细胞转移中的作用。我们的数据显示，使用针对CXCR 4的siRNA下调CXCR 4表达可显著降低CpG ODN诱导的95 D细胞的体内外转移增强。提示TLR 9激动剂可能通过CXCR 4/SDF-1途径促进人肺癌细胞的转移。(C)2009 Elsevier Inc. All rights reserved.
Accumulating data suggested that CXCR4/SDF-1 pathway may play an important role in the metastasis of tumor. We previously demonstrated that CpG ODN could enhance the metastasis of human lung cancer cell via TLR9. Here we further evaluated the possible role of CXCR4/SDF-1 pathway in the enhanced metastasis of human lung cancer 95D cells induced by CpG ODN. Our data showed down-regulation of CXCR4 expression using siRNA against CXCR4 could significantly reduce the enhanced metastasis of 95D cells induced by CpG ODN both in vitro and in vivo. These results suggested that TLR9 agonist might promote the metastasis of human lung cancer cells via CXCR4/SDF-1 pathway. (C) 2009 Elsevier Inc. All rights reserved.