The blood brain barrier in HIV infection
The blood brain barrier in HIV infection
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DOI：
10.2741/1427
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发表时间：
2004-09-01
影响因子：
3.1
通讯作者：
Avison, M
中科院分区：
文献类型：
--
作者：
Berger, JR;Avison, M
血脑屏障（BBB）是大脑的保护机制。它阻止有害物质进入中枢神经系统，无论是化学物质还是细胞物质。从本质上讲，它是一种保护大脑内部环境的防御机制。血脑屏障可被许多病理过程破坏。CNS感染是公认的BBB破坏的原因。在已证实影响BBB的CNS感染中，有人类免疫缺陷病毒（HIV）。艾滋病毒在感染后不久就会感染大脑。脑脊液（CSF）的研究以及对比增强磁共振成像的动态研究证实了HIV感染者的血脑屏障异常。CNS的病理学研究已经证实了体内研究，体外研究已经确定了一系列HIV相关BBB损害的致病机制。血脑屏障的破坏不仅可能加速HIV的脑感染，而且可能改变CNS功能。此外，血脑屏障破坏与抗逆转录病毒治疗有关。本次审查将解决这些问题。
The blood brain barrier (BBB) serves as a protective mechanism for the brain. It prevents entry of pernicious substances, whether chemical or cellular, from free access to the CNS. In essence, it is a defense mechanism preserving the internal milieu of the brain. The BBB may be disrupted by a number of pathological processes. CNS infection is a well recognized cause of BBB disruption. Among the CNS infections demonstrated to affect the BBB is human immunodeficiency virus (HIV). HIV infects the brain shortly after its acquisition. Studies of cerebrospinal fluid (CSF) as well as dynamic studies of contrast enhanced magnetic resonance imaging have confirmed abnormalities of the BBB in HIV-infected persons. Pathological studies of the CNS have confirmed the in vivo studies, and in vitro studies have identified a range of pathogenic mechanisms of HIV-associated BBB compromise. This disruption of the BBB may not only contribute to accelerating brain infection by HIV, but may also alter CNS function. Additionally, BBB disruption has implications with respect to antiretroviral therapy. This review will address these issues.