Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases
Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases
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DOI：
10.1021/np070115h
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发表时间：
2007-06-01
影响因子：
5.1
通讯作者：
Jansen, Rolf
中科院分区：
文献类型：
--
作者：
Irschik, Herbert;Schummer, Dietmar;Jansen, Rolf
从苏氏粘杆菌、SOCE750和SOCE1045的发酵液中分离得到一种新的大环内酯类抗生素Etngien(1)，它对革兰氏阳性菌有抑制作用。对化合物1的波谱结构分析表明，1是一个含有修饰的C-21羧酸侧链的大环内酯化合物。后者含有两个烯丙基羟基和一个全E六烯基团，提供了特征的UV生色团1。对作用机制的初步研究表明，etngien(1)对细菌和病毒核酸聚合酶有抑制作用。
Etnangien (1), a new macrolide antibiotic active against Gram-positive bacteria, was isolated from the culture broth of the myxobacterium Sorangium cellulosum, strains So ce750 and So ce1045. Spectroscopic structure elucidation of 1 revealed a complex macrocyclic lactone bearing a modified C-21 carboxylic acid side chain. The latter contains two allylic hydroxyl groups and an all-E hexaene unit, which provides the characteristic UV chromophore of 1. Initial studies toward the mechanism of action showed that bacterial and viral nucleic acid polymerases are inhibited by etnangien (1).