Pediatric Auditory Brainstem Implantation: Surgical, Electrophysiologic, and Behavioral Outcomes.
Pediatric Auditory Brainstem Implantation: Surgical, Electrophysiologic, and Behavioral Outcomes.
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DOI：
10.1097/aud.0000000000000501
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Buchman CA
中科院分区：
文献类型：
--
作者：
Teagle HFB;Henderson L;He S;Ewend MG;Buchman CA
证明听觉脑干植入（ABI）手术的安全性以及随后在无神经纤维瘤病II型（NFII）儿童中听觉和口语技能的发展。在查佩尔山的北卡罗来纳州大学进行了一项关于无NFII儿童ABI的前瞻性、单一受试者观察性研究。5名儿童根据研究者申办的试验用器械豁免（IDE）入组。在3年内，收集了患者人口统计学资料、医疗/手术结果、并发症、器械标测、电生理测量、听力学结局以及言语和语言测量。迄今为止，5名无NFII的儿童接受了ABI治疗，没有永久性的医学后遗症，尽管2名儿童在手术后因暂时性并发症需要治疗。所有的孩子每天都戴着他们的设备，声音意识的好处发展缓慢。术中和术后电生理测量增强手术放置和器械程控。听力技能的缓慢发展在言语产生方面造成了有限的变化，但对口语的发展几乎没有影响。ABI手术在没有NFII的幼儿中是安全的。器械使用的益处发展缓慢，包括声音意识以及声音模式和时间方面的使用。这些技能可能会增加言语产生的进展，但语言发展的进展取决于视觉交流。需要对该队列进行进一步监测，以更好地描述该干预在该患者人群中的获益。
Demonstrate the safety of auditory brainstem implant (ABI) surgery and the subsequent development of auditory and spoken language skills in children without Neurofibromatosis type II (NFII). A prospective, single-subject observational study of ABI in children without NFII was undertaken at the University of North Carolina at Chapel Hill. Five children were enrolled under an Investigational Device Exemption (IDE) sponsored by the investigators. Over 3 years, patient demographics, medical/surgical findings, complications, device mapping, electrophysiological measures, audiological outcomes and speech and language measures were collected. Five children without NFII have received ABIs to date without permanent medical sequelae, although 2 children required treatment after surgery for temporary complications. All children wear their device daily and the benefits of sound awareness have developed slowly. Intra-and post-operative electrophysiological measures augmented surgical placement and device programming. The slow development of audition skills precipitated limited changes in speech production but had little impact upon growth in spoken language. ABI surgery is safe in young children without NFII. Benefits from device use develop slowly and include sound awareness and the use of pattern and timing aspects of sound. These skills may augment progress in speech production but progress in language development is dependent upon visual communication. Further monitoring of this cohort is needed to better delineate the benefits of this intervention in this patient population.