Development of diffuse large B-cell lymphoma in a patient with Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms.
Development of diffuse large B-cell lymphoma in a patient with Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms.
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DOI：
10.4081/hr.2011.e10
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发表时间：
2011-08-31
影响因子：
0.9
通讯作者：
Motoji T
中科院分区：
文献类型：
--
作者：
Shiseki M;Masuda A;Watanabe N;Fujii M;Kimura T;Yoshinaga K;Mori N;Teramura M;Motoji T
Waldenström‘s巨球蛋白血症(WM)/淋巴浆细胞性淋巴瘤(LPL)是一种惰性成熟的B细胞肿瘤。在罕见的WM/LPL病例中，弥漫性大B细胞淋巴瘤(DLBCL)是组织学转化的结果。在这篇报告中，我们报告一位西医/LPL患者发生DLBCL的病例。联合化疗对DLBCL有效，最终达到完全缓解。我们试图通过分析免疫球蛋白重链基因中的互补决定区3(CDR3)来确定WM/LPL与DLBCL之间的克隆相关性。在DLBCL和WM/LPL的肿瘤细胞中发现了一个共同的CDR3序列，表明DLBCL的肿瘤细胞在克隆上与WM/LPL的肿瘤细胞相同。因此，在本研究中，DLBCL是从WM/LPL细胞克隆进化而来的。
Waldenström's macroglobulinemia (WM)/ lymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell neoplasm. In rare cases of WM/LPL, diffuse large B-cell lymphoma (DLBCL) develops as a result of histologic transformation. In this report, we present a case of DLBCL developing in a patient with WM/LPL. Combination chemotherapy for DLBCL was effective and complete remission was eventually achieved. We attempted to determine the clonal relatedness between WM/LPL and DLBCL in the patient by analyzing complementarity-determining region 3 (CDR3) in the immunoglobulin heavy chain gene. A common CDR3 sequence was found in tumor cells of DLBCL and those of WM/LPL, indicating that tumor cells of DLBCL are clonally identical to those of WM/LPL. Therefore, in the present case, DLBCL is developed from WM/LPL cells by clonal evolution.