Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome.
Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome.
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DOI：
10.1007/s11914-015-0292-x
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发表时间：
2015-12
影响因子：
4.3
通讯作者：
Parameswaran N
中科院分区：
文献类型：
--
作者：
McCabe L;Britton RA;Parameswaran N
我们对肠道微生物组如何促进健康和疾病的理解的最新进展，已经引起了人们对开发用于调节微生物丰度和/或其活性以改善整体人类健康和预防诸如骨质疏松症等病理的策略的极大兴趣。骨是一个器官，肠道通过吸收钙来调节，钙是关键的骨矿物质。然而，很明显，肠道及其微生物组的调节可以影响各种动物模型（斑马鱼，啮齿动物，鸡）和人类的骨密度和强度。这在通过抗生素治疗或使用无菌小鼠条件消除微生物组的研究以及通过益生元和/或益生菌治疗调节微生物组活性和组成的研究中得到证实。这篇评论将讨论在这个新的和令人兴奋的领域的最新发展。
Recent advances in our understanding of how the intestinal microbiome contributes to health and disease have generated great interest in developing strategies for modulating the abundance of microbes and/or their activity to improve overall human health and prevent pathologies such as osteoporosis. Bone is an organ that the gut has long been known to regulate through absorption of calcium, the key bone mineral. However, it is clear that modulation of the gut and its microbiome can affect bone density and strength in a variety of animal models (zebra fish, rodents, chicken) and humans. This is demonstrated in studies ablating the microbiome through antibiotic treatment or using germ-free mouse conditions as well as in studies modulating the microbiome activity and composition through prebiotic and/or probiotic treatment. This review will discuss recent developments in this new and exciting area.