Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170.
Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170.
复制标题
钙蛋白酶抑制剂 MDL28170 可改善中度缺氧后的神经元恢复。
DOI：
10.1016/s0006-8993(97)00848-2
复制
发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Lee,KS
中科院分区：
文献类型：
--
作者：
Chen,ZF;Schottler,F;Lee,KS
钙活化蛋白水解在缺氧神经元损伤中的作用通过模拟缺血半暗带许多特征的中度缺氧体外切片模型进行了研究。calpain抑制剂MDL28170在无缺氧去极化的情况下，可显著改善长时间中度缺氧后海马切片突触反应的恢复。这一发现进一步暗示calpain介导的蛋白水解在中度代谢刺激（如部分缺血区域）后神经元损伤的发展中起作用。
The role of calcium-activated proteolysis in hypoxic neuronal injury was investigated using an in vitro slice model of moderate hypoxia that mimics many features of an ischemic penumbra. The calpain inhibitor, MDL28170, significantly improved the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization. This finding further implicates calpain-mediated proteolysis in the development of neuronal injury following moderate metabolic challenge such as occurs in regions of partial ischemia.