QUANTIFICATION OF NERVE-FIBER LAYER THICKNESS IN NORMAL AND GLAUCOMATOUS EYES USING OPTICAL COHERENCE TOMOGRAPHY - A PILOT-STUDY
QUANTIFICATION OF NERVE-FIBER LAYER THICKNESS IN NORMAL AND GLAUCOMATOUS EYES USING OPTICAL COHERENCE TOMOGRAPHY - A PILOT-STUDY
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DOI：
10.1001/archopht.1995.01100050054031
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发表时间：
1995-05-01
影响因子：
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通讯作者：
FUJIMOTO, JG
中科院分区：
文献类型：
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作者：
SCHUMAN, JS;HEE, MR;FUJIMOTO, JG
目的：定量评估正常眼和青光眼眼的神经纤维层（NFL）厚度，并与常规测量的视神经结构和功能的相关性。方法：我们研究了33名受试者的59只眼，采用常规眼科体检、Humphrey 24-2视野、立体视神经乳头摄影和光学相干断层扫描。结果：通过光学相干断层扫描测量的神经纤维层厚度与通过视野检查测量的视神经功能状态高度相关（P=.0001）。无论是视神经杯状还是神经视网膜边缘区域与视野丧失的相关性都不如NFL厚度（分别为P= 0.17和P= 0.21）。只有当杯子很小（杯径比，0.1至0.3）或很大（杯径比，0.8至1.0）时，拔罐与NFL厚度相关（P= 0.006）;否则，拔罐与NFL厚度之间没有相关性。神经纤维层，特别是在下象限，在青光眼的眼睛比正常的眼睛显着薄（P= 0.04）。最后，我们发现NFL厚度随着年龄的增长而减少，即使控制了与青光眼诊断相关的因素（P=.03）。结论：神经纤维层厚度可以使用光学相干断层扫描测量。这些测量提供了与已知参数的良好的结构和功能相关性。
Purpose: Quantitative assessment of nerve fiber layer (NFL) thickness in normal and glaucomatous eyes, and correlation with conventional measurements of the optic nerve structure and function.Methods: We studied 59 eyes of 33 subjects by conventional ophthalmologic physical examination, Humphrey 24-2 visual fields, stereoscopic optic nerve head photography, and optical coherence tomography.Results: Nerve fiber layer thickness as measured by optical coherence tomography demonstrated a high degree of correlation with functional status of the optic nerve, as measured by visual field examination (P=.0001). Neither cupping of the optic nerve nor neuroretinal rim area were as strongly associated with visual field loss as was NFL thickness (P=.17 and P=.21, respectively). Cupping correlated with NFL thickness only when the cup was small (cup-to-diameter ratio, 0.1 to 0.3) or large (cup-to-diameter ratio, 0.8 to 1.0) (P=.006); there was no correlation between cupping and NFL thickness otherwise. Nerve fiber layer, especially in the inferior quadrant, was significantly thinner in glaucomatous eyes than in normal eyes (P=.04). Finally, we found a decrease in NFL thickness with aging, even when controlling for factors associated with the diagnosis of glaucoma (P=.03).Conclusions: Nerve fiber layer thickness can be measured using optical coherence tomography. These measurements provide good structural and functional correlation with known parameters.